CAS 124478-60-0

Aglepristone

Description:

Aglepristone, with the CAS number 124478-60-0, is a synthetic steroid and a selective progesterone receptor antagonist. It is primarily used in veterinary medicine, particularly for the termination of pregnancy in dogs and for managing certain reproductive disorders. The compound works by blocking the action of progesterone, a hormone crucial for maintaining pregnancy, thereby inducing abortion or facilitating the expulsion of the fetus. Aglepristone is characterized by its high affinity for progesterone receptors, which allows it to effectively inhibit the physiological effects of progesterone. In terms of physical properties, it is typically a white to off-white crystalline powder, and it is soluble in organic solvents. The substance is administered via injection, and its pharmacological effects are generally reversible upon cessation of treatment. Safety and efficacy have been established in veterinary applications, but it is important to note that its use in humans is not approved and should be approached with caution.

Formula: C₂₉H₃₇NO₂

InChI: InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1

InChI key: InChIKey=RTCKAOKDXNYXEH-FWSJOHTJSA-N

SMILES: C[C@@]12[C@]([C@]3(C([C@H](C1)C4=CC=C(N(C)C)C=C4)=C5C(CC3)=CC(=O)CC5)[H])(CC[C@]2(/C=C\C)O)[H]

Synonyms:

• (11beta,17alpha)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-[(1Z)-prop-1-en-1-yl]estra-4,9-dien-3-one
• (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1Z)-1-propen-1-ylestra-4,9-dien-3-one
• 11β-[p-(Dimethylamino)phenyl]-17β-hydroxy-17-[(Z)-propenyl]estra-4,9-dien-3-one
• Alizine
• Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1-propenyl)-, [11β,17β,17(Z)]-
• Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1Z)-1-propen-1-yl-, (11β,17β)-
• Estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-(1Z)-1-propenyl-, (11β,17β)-
• Ru 534
• estra-4,9-dien-3-one, 11-[4-(dimethylamino)phenyl]-17-hydroxy-17-[(1Z)-1-propen-1-yl]-, (11beta,17alpha)-
• Aglepristone
• (8S,11R,13S,14S,17S)-11-(4-Dimethylaminophenyl)-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Aglepristone

CAS: 124478-60-0

Formula: C₂₉H₃₇NO₂

Color and Shape: Solid

Molecular weight: 431.6096

Ref: IN-DA000M2T

Aglepristone

CAS: 124478-60-0

Formula: C₂₉H₃₇NO₂

Color and Shape: Yellow Solid

Molecular weight: 431.62

Ref: 4Z-A-220001

Aglepristone

CAS: 124478-60-0

Aglepristone: synthetic steroid, antiprogestogen, some antiglucocorticoid effect, used as abortifacient in animals.

Formula: C₂₉H₃₇NO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 431.62

Ref: TM-T21132

Aglepristone

Controlled Product

CAS: 124478-60-0

Aglepristone is a progesterone receptor antagonist. It blocks the action of progesterone by binding to the progesterone receptor and preventing it from functioning, thereby inducing abortion. Aglepristone has also been shown to be effective in treating endometrial cancer and pyometra.

Purity: Min. 95%

Molecular weight: 431.61 g/mol

Ref: 3D-FA39376

Aglepristone

CAS: 124478-60-0

Applications Aglepristone is used as a treatment to induce parturition in ewes and their newborns. A competitive progesterone antagonist for treatment of various progesterone-dependent physiology and pathology conditions, and effective means of terminating pregnancy in most species. Also, it prevents sperm progression toward the oviducts and fertilization in inseminated females.
References Ozalp, R. G., et al.: Theriogenology, 87, 141-147 (2017); Gogny, A., et al.: Theriogenology, 85, 555-566 (2016); Reynaud, K., et al.: Biol. Reprod., 93, 1-9 (2015)

Formula: C₂₉H₃₇NO₂

Color and Shape: Neat

Molecular weight: 431.61

Ref: TR-A430055

Aglepristone

CAS: 124478-60-0

Formula: C₂₉H₃₇NO₂

Molecular weight: 431.62

Ref: ST-EA-CP-A307000