CAS 124485-41-2

Z-Val-Val-Arg-AMC

Description:

Z-Val-Val-Arg-AMC, also known as Z-Val-Val-Arginine-7-amido-4-methylcoumarin, is a synthetic peptide substrate commonly used in biochemical research, particularly in the study of proteases. The "Z" in its name indicates that it is a benzyloxycarbonyl derivative, which serves to protect the amino group of the N-terminal valine, enhancing its stability and solubility. The structure features a sequence of amino acids, including valine and arginine, linked to a 7-amido-4-methylcoumarin moiety, which acts as a fluorescent reporter. This compound is often employed in assays to monitor proteolytic activity, as the cleavage of the peptide bond by specific enzymes releases the fluorescent coumarin, allowing for quantification. Its characteristics include high specificity for certain proteases, good solubility in aqueous solutions, and the ability to provide real-time monitoring of enzymatic reactions. Overall, Z-Val-Val-Arg-AMC is a valuable tool in enzymology and related fields for studying enzyme kinetics and mechanisms.

Formula: C₃₄H₄₅N₇O₇

Z-Val-Val-Arg-AMC · HCl

CAS: 124485-41-2

Z-Val-Val-Arg-AMC · HCl is a substrate of human and canine cathepsin S. Z-Val-Val-Arg-AMC · HCl is also cleaved by falcipain-related enzymes from Plasmodium species.

Formula: C₃₄H₄₅N₇O₇·HCl

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 700.22

Ref: 01-4016422

Z-Val-Val-Arg-AMC

CAS: 124485-41-2

Z-Val-Val-Arg-AMC serves as a fluorescent peptide substrate utilized for assessing the activity of cathepsins [1].

Formula: C₃₄H₄₅N₇O₇

Color and Shape: Solid

Molecular weight: 663.76

Ref: TM-T87681

Z-Val-Val-Arg-AMC

CAS: 124485-41-2

Z-Val-Val-Arg-AMC is a protease inhibitor that inhibits the activity of the ubiquitin-proteasome pathway. It was first synthesized in an attempt to inhibit the activity of cathepsin B, but it was found to inhibit other proteases and is now used as a research reagent. Z-Val-Val-Arg-AMC has been shown to have pharmacokinetic properties similar to those of zwitterionic drugs, which may be due to its high degree of water solubility. This drug also has antiinflammatory and antiproteolytic effects and may have potential use in the treatment of cancer and autoimmune diseases. Z-Val-Val-Arg-AMC inhibits autophagy by inhibiting lysosomal degradation mediated by autophagy protein LC3B and plays a role in apoptosis.

Formula: C₃₄H₄₅N₇O₇

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 663.76 g/mol

Ref: 3D-FV49239

Z-Val-Val-Arg-AMC

CAS: 124485-41-2

Z-Val-Val-Arg-AMC is a synthetic peptide that activates the glycine receptor. It has been shown to inhibit ion channel function in a rat model of epilepsy, and also to block the binding of an antibody against the glycine receptor. The peptide was synthesized by coupling L-valine, L-valylglycine, and L-arginine with methyl 2-(4'-methylaminophenyl) acetate. Z-Val-Val-Arg-AMC is a high purity product that has been shown to be useful in cell biology research as a tool for studying ligand/receptor interactions.

Formula: C₃₄H₄₅N₇O₇

Purity: Min. 95%

Molecular weight: 663.76 g/mol

Ref: 3D-MCA-3211-V