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CAS 1245-13-2

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Bicinchoninic acid

Description:
Bicinchoninic acid (BCA) is a chemical compound widely used in biochemistry and molecular biology, particularly for protein quantification assays. It is characterized by its ability to form a stable complex with cuprous ions (Cu^+), which are generated from the reduction of cupric ions (Cu^2+) in alkaline conditions. This complex exhibits a strong absorbance at a specific wavelength, allowing for the quantification of proteins based on colorimetric analysis. BCA is a diketone, featuring two chinone groups that contribute to its reactivity and complexation properties. It is soluble in water and exhibits good stability under various conditions, making it suitable for laboratory applications. The BCA assay is favored for its sensitivity, compatibility with various detergents, and the ability to measure protein concentrations in the presence of reducing agents. Additionally, bicinchoninic acid is often utilized in conjunction with other reagents to enhance assay performance, making it a versatile tool in protein research and analysis.
Formula:C20H12N2O4
InChI:InChI=1S/C20H12N2O4/c23-19(24)13-9-17(21-15-7-3-1-5-11(13)15)18-10-14(20(25)26)12-6-2-4-8-16(12)22-18/h1-10H,(H,23,24)(H,25,26)
InChI key:InChIKey=AFYNADDZULBEJA-UHFFFAOYSA-N
SMILES:C(O)(=O)C=1C2=C(N=C(C1)C=3C=C(C(O)=O)C4=C(N3)C=CC=C4)C=CC=C2
Synonyms:
  • (2,2′)Biquinolinyl-4,4′-dicarboxylic acid
  • 2,2'-Bicinchoninic Acid
  • 2,2′-Dicinchoninic acid
  • 2-(4-Carboxyquinolin-2-yl)quinoline-4-carboxylic acid
  • 4,4′-Dicarboxy-2,2′-biquinoline
  • Bicinchoninic acid
  • NSC 133815
  • [2,2′-Biquinoline]-4,4′-dicarboxylic acid
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