CAS 124508-66-3

Triptorelin pamoate

Description:

Triptorelin pamoate is a synthetic peptide and a gonadotropin-releasing hormone (GnRH) analog, primarily used in the treatment of hormone-sensitive conditions such as prostate cancer and endometriosis. It functions by initially stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to a temporary increase in sex hormone levels. However, with continuous administration, it results in downregulation of GnRH receptors, ultimately decreasing the production of sex hormones. Triptorelin pamoate is characterized by its high potency and long half-life, which allows for extended therapeutic effects with less frequent dosing. The substance is typically administered via intramuscular injection and is known for its stability and solubility in aqueous solutions. Its molecular structure includes a pamoic acid moiety, which contributes to its prolonged action. As with any medication, potential side effects may include hot flashes, decreased libido, and other hormonal-related changes, necessitating careful monitoring during treatment.

Formula: C₈₇H₉₈N₁₈O₁₉

InChI: InChI=1/C68H90N16O13.C23H16O6.H3N/c1-4-73-48-14-8-6-12-42(48)21-24-51(79-61(91)44(31-45-34-72-38-76-45)33-57(87)50-25-26-60(90)77-50)62(92)83-55(37-85)66(96)81-53(30-40-17-22-46(86)23-18-40)64(94)82-54(32-43-20-19-41-11-5-7-13-47(41)43)65(95)80-52(29-39(2)3)63(93)78-49(15-9-27-74-68(70)71)58(88)36-84-28-10-16-56(84)67(97)75-35-59(69)89;24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;/h4-8,11-14,17-18,20,22-23,34,38-39,44,49-56,73,85-86H,1,9-10,15-16,19,21,24-33,35-37H2,2-3H3,(H2,69,89)(H,72,76)(H,75,97)(H,77,90)(H,78,93)(H,79,91)(H,80,95)(H,81,96)(H,82,94)(H,83,92)(H4,70,71,74);1-10,24-25H,11H2,(H,26,27)(H,28,29);1H3

SMILES: C=CNc1ccccc1CCC(C(=NC(CO)C(=NC(Cc1ccc(cc1)O)C(=NC(CC1=CCc2ccccc12)C(=NC(CC(C)C)C(=NC(CCCNC(=N)N)C(=O)CN1CCCC1C(=NCC(=N)O)O)O)O)O)O)O)N=C(C(Cc1cnc[nH]1)CC(=O)C1CCC(=N1)O)O.c1ccc2c(c1)cc(c(c2Cc1c2ccccc2cc(c1O)C(=O)O)O)C(=O)O.N

Synonyms:

• Triptorelin pamoate [USAN]
• 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolylglycine amide, 4,4'-methylenebis(3-hydroxy-2-naphthoate) (salt)
• Decapeptyl
• Luteinizing hormone-releasing factor (swine), 6-D-tryptophan-, 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylate) (salt)
• Pamorelin
• Trelstar
• Trelstar LA
• Trelstar depot
• Unii-08An7Wa2G0
• 2-Naphthalenecarboxylic acid, 4,4'-methylenebis(3-hydroxy-, compd. with 6-D-tryptophanluteinizing hormone-releasing factor (pig)
• TriptorelinPamoate

Triptorelin Pamoate

CAS: 124508-66-3

Formula: C₆₄H₈₂N₁₈O₁₃C₂₃H₁₆O₆

Molecular weight: 1311.47 : 388.4

Ref: ST-EA-CP-T191001

Triptorelin pamoate

CAS: 124508-66-3

Triptorelin is a GnRH agonist for treating hormone cancers, precocious puberty, and endometriosis, and used in assisted reproduction.

Formula: C₈₇H₉₈N₁₈O₁₉

Color and Shape: Solid

Molecular weight: 1699.85

Ref: TM-T71149

(D-Trp6)-LHRH pamoate salt

CAS: 124508-66-3

The hormone LHRH is a decapeptide that stimulates the production of gonadotropins, which stimulate the synthesis and release of sex hormones. LHRH has been used for the treatment of prostate cancer. It can be administered in the form of a long-acting ester formulation, such as the pamoate salt (Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly), or as an analog, such as triptorelin acetate. The analogs are more potent than LHRH and have greater efficacy in preventing tumor growth and inducing regression. Analogs may be administered in microcapsules for extended release or orally to provide higher levels of drug at target sites. The ester linkages between amino acids allow for a sustained release of LHRH over time. These esters are hydrolyzed by enzymes present in plasma and tissues, releasing active LHRH into circulation that binds

Formula: C₆₄H₈₂N₁₈O₁₃·xC₂₃H₁₆O₆

Purity: Min. 95%

Molecular weight: 1,311.45 g/mol

Ref: 3D-FT109737