CAS 1245157-42-9

Dasatinib Impurity 34

CAS: 1245157-42-9

Formula: C₁₅H₂₀N₆O₃S

Molecular weight: 364.42

Ref: 4Z-D-3046

2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid

Controlled Product

CAS: 1245157-42-9

Applications 2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid is an intermediate in the preparation of Dasatinib (D193600), a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic.
References Lombardo, L.J., et al: J. Med. Chem., 47, 6658 (2004); Shah, N. P., et al.: Science, 305, 399 (2004); O’Hare, T., et al.: Curr. Opin. Genet. Dev., 16, 92 (2006); Yan, R., et al.: Faming Zhuanli Shenqing (2010), CN 101845045 A 20100929

Formula: C₁₅H₂₀N₆O₃S

Color and Shape: Neat

Molecular weight: 364.42

Ref: TR-H939020

Dasatinib Hydrolytic Impurity

CAS: 1245157-42-9

Formula: C₁₅H₂₀N₆O₃S

Molecular weight: 364.42

Ref: ST-EA-CP-D1031