CAS 1245537-68-1

BGT226

Description:

BGT226, with the CAS number 1245537-68-1, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is classified as a small molecule inhibitor, specifically targeting certain pathways involved in cellular signaling and proliferation. BGT226 is known to inhibit the activity of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR), which are crucial in regulating cell growth, survival, and metabolism. This inhibition can lead to the suppression of tumor growth, making it a candidate for cancer treatment. The compound is typically characterized by its specific molecular structure, which includes various functional groups that contribute to its biological activity. Additionally, BGT226 has been studied for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), which are essential for understanding its efficacy and safety profile in clinical settings. As research continues, further insights into its mechanism of action and potential side effects are being explored.

Formula: C₂₈H₂₅F₃N₆O₂·C₄H₄O₄

Synonyms:

• BGT-226 maleate
• 1-(3-(Trifluoromethyl)-4-(piperazin-1-yl)phenyl)-8-(6-methoxypyridin-3-yl)-3-methyl-1H-imidazo[4,5-c]quinolin-2(3H)-one maleic acid salt
• 8-(6-methoxypyridin-3-yl)-3-methyl-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1H-imidazo[4,5-c]quinolin-2(3H)-one Maleic acid
• NVP-BGT226
• BGT226 maleate (NVP-BGT226 maleate)
• BGT226 (NVP-BGT226)
• NVP-BGT226 (maleate)
• NVP-BGT226 (BGT226)
• NVP-BGT226 USP/EP/BP
• CS-382
• BGT226 (NVP-BGT226);NVP-BGT226
• BGT-226;NVP BGT226 (BGT226)
• BGT-226 (Maleic Acid Salt)
• NVP-BGT226 (free base)
• (Z)-but-2-enedioic acid,8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]imidazo[4,5-c]quinolin-2-one
• 8-(6-Methoxypyridin-3-yl)-3-methyl-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1H-imidazo
• BGT226

BGT226 (NVP-BGT226)

CAS: 1245537-68-1

Formula: C₃₂H₂₉F₃N₆O₆

Purity: 99%

Color and Shape: Solid

Molecular weight: 650.6045

Ref: IN-DA009CDX

BGT226 maleate

CAS: 1245537-68-1

BGT226 maleate

Purity: ≥95%

Molecular weight: 650.6g/mol

Ref: 54-BUP12521

BGT226 maleate

CAS: 1245537-68-1

Ref: 7W-GW3237

BGT226 maleate

CAS: 1245537-68-1

BGT226 maleate (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .

Formula: C₂₈H₂₅F₃N₆O₂·C₄H₄O₄

Purity: 97.75% - 98.78%

Color and Shape: Solid

Molecular weight: 650.6

Ref: TM-T6072

BGT 226

Controlled Product

CAS: 1245537-68-1

Applications BGT 226 is a novel phosphatidyl inositol-3 kinase/mammalian target of rapamycin (PI3K/mTOR ) dual inhibitor which has shown to be effective with gefitinib in epidermal growth factor receptor (EGFR) inhibitor-sensitive non-small cell lung cancer (NSCLC) therapy.
References Katanasaka, Y., et. al.: Cancer Lett., 347, 196 (2014)

Formula: C₃₂H₂₉F₃N₆O₆

Color and Shape: Neat

Molecular weight: 650.6

Ref: TR-B367500

NVP BGT 226

CAS: 1245537-68-1

Class I PI3K/mTOR dual inhibitor; antineoplastic

Formula: C₂₈H₂₅F₃N₆O₂•C₄H₄O₄

Purity: Min. 95%

Molecular weight: 650.6 g/mol

Ref: 3D-FN104017