CAS 1246086-78-1

VU 0364439

Description:

VU 0364439, with the CAS number 1246086-78-1, is a chemical compound that has garnered attention in the field of neuroscience and pharmacology. It is primarily recognized as a selective antagonist of the metabotropic glutamate receptor subtype 2 (mGluR2). This receptor plays a crucial role in modulating neurotransmission and is implicated in various neurological disorders. VU 0364439 has been studied for its potential therapeutic effects in conditions such as anxiety, depression, and schizophrenia, as it may help to balance glutamatergic signaling in the brain. The compound is characterized by its ability to inhibit receptor activity, which can lead to alterations in synaptic plasticity and neuronal excitability. Its pharmacological profile suggests that it may have a favorable safety and efficacy profile, making it a candidate for further research in drug development. However, detailed studies on its pharmacokinetics, toxicity, and long-term effects are essential for understanding its full potential and applications in clinical settings.

Formula: C₁₈H₁₃Cl₂N₃O₃S

Synonyms:

• N-(3-chloro-4-(N-(2-chlorophenyl)sulfamoyl)phenyl)picolinamide
• 2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-
• Vu0364439
• N-[3-chloro-4-[(2-chlorophenyl)sulfamoyl]phenyl]pyridine-2-carboxamide
• N-(3-Chloro-4-(((2-chlorophenyl)amino)sulfonyl)phenyl)-2-pyridinecarboxamide
• N-{3-Chloro-4-[(2-chlorophenyl)sulfamoyl]phenyl}-2-pyridinecarboxamide
• Vu-0364439

2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]-

CAS: 1246086-78-1

Formula: C₁₈H₁₃Cl₂N₃O₃S

Purity: 98%

Molecular weight: 422.2851

Ref: IN-DA000MGG

VU 0364439

CAS: 1246086-78-1

VU 0364439

Purity: ≥95%

Molecular weight: 422.29g/mol

Ref: 54-BUP04426

VU 0364439

CAS: 1246086-78-1

VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM).

Formula: C₁₈H₁₃Cl₂N₃O₃S

Purity: 97.9%

Color and Shape: Solid

Molecular weight: 422.29

Ref: TM-T6160

VU 0364439

CAS: 1246086-78-1

VU 0364439 is a negative allosteric modulator (NAM) of the metabotropic glutamate receptor 5 (mGlu5), which is sourced from synthetic chemical libraries. Its mode of action involves selectively binding to the mGlu5 receptor, thereby inhibiting its function by interfering with glutamate signaling without competing at the active site. This modulation affects various downstream signaling pathways involved in numerous neurological processes.

Formula: C₁₈H₁₃Cl₂N₃O₃S

Purity: Min. 95%

Molecular weight: 422.29 g/mol

Ref: 3D-WZB08678