CAS 1246303-14-9

VU0359595

CAS: 1246303-14-9

VU0359595 (ML-270) is a selective PLD1 inhibitor with 3.7 nM IC50; >1700x more selective over PLD2, for cancer/diabetes/neurodegenerative research.

Formula: C₂₅H₂₉BrN₄O₂

Purity: 99.79%

Color and Shape: Solid

Molecular weight: 497.43

Ref: TM-T21777

Cyclopropanecarboxamide, N-[(1S)-2-[4-(5-bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-phenyl-, (1R,2R)-

CAS: 1246303-14-9

Formula: C₂₅H₂₉BrN₄O₂

Purity: 95%

Molecular weight: 497.4274

Ref: IN-DA000MHY

VU0359595

CAS: 1246303-14-9

VU0359595

Purity: ≥98%

Molecular weight: 497.43g/mol

Ref: 54-BUP14356

VU0359595

CAS: 1246303-14-9

VU0359595 is a selective negative allosteric modulator that targets the metabotropic glutamate receptor 5 (mGluR5), which is primarily sourced from synthetic chemical libraries. This compound acts by binding to a site distinct from the active site on mGluR5, effectively inhibiting the receptor's activity without directly competing with endogenous ligands. By altering the receptor's conformation, VU0359595 modulates downstream signaling pathways, which can be pivotal in understanding synaptic transmission and plasticity.

Formula: C₂₅H₂₉BrN₄O₂

Purity: Min. 95%

Molecular weight: 497.43 g/mol

Ref: 3D-WZB30314