CAS 1246819-87-3

Plerixafor

Description:

Plerixafor, with the CAS number 1246819-87-3, is a small molecule that functions primarily as a chemokine receptor antagonist, specifically targeting the CXCR4 receptor. It is known for its role in mobilizing hematopoietic stem cells into the bloodstream, making it valuable in clinical settings, particularly in the treatment of certain types of cancers and in stem cell transplantation. Plerixafor is typically administered via subcutaneous injection and is often used in conjunction with other therapies to enhance stem cell collection for patients undergoing autologous stem cell transplantation. The substance is characterized by its ability to inhibit the interaction between the CXCR4 receptor and its ligand, CXCL12, thereby disrupting the retention of stem cells in the bone marrow. This mechanism of action is crucial for improving the efficacy of stem cell mobilization. Plerixafor is generally well-tolerated, though it may have side effects, including injection site reactions and gastrointestinal disturbances. Its development has significantly advanced the field of hematology and oncology, providing new avenues for patient treatment.

Formula: C₂₈H₅₄N₈

Synonyms:

• [2H4]-Plerixafor
• Plerixafor-d4

Plerixafor-d4

Controlled Product

CAS: 1246819-87-3

Stability Very Hygroscopic
Applications Labelled Plerixafor, it is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).
References Xie, T., et al.: Science, 290, 328 (2000), Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2003), Chigaev, A., et al.: J. Immunol. 178, 6828 (2007), Kiel, M., et al.: Cell Stem Cell, 1, 204 (2007),

Formula: C₂₈H₅₀D₄N₈

Color and Shape: Off White Solid

Molecular weight: 506.81

Ref: TR-P580502

Plerixafor-d4

CAS: 1246819-87-3

Plerixafor-d4 is an isotopically-labeled compound, specifically a deuterium-labeled analog of plerixafor, which is a small-molecule antagonist of the C-X-C chemokine receptor type 4 (CXCR4). This synthetic compound is designed to facilitate studies in receptor binding and mechanism elucidation by providing a stable isotope label useful in pharmacokinetics and bioanalytical applications.

Formula: C₂₈H₅₄N₈

Purity: Min. 95%

Molecular weight: 506.8 g/mol

Ref: 3D-WZB81987