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CAS 1246820-35-8

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Desacetyl Diltiazem-d6

Description:
Desacetyl Diltiazem-d6 is a deuterated derivative of diltiazem, a calcium channel blocker commonly used in the treatment of hypertension and angina. The "desacetyl" prefix indicates that the acetyl group has been removed from the diltiazem structure, which can influence its pharmacological properties. The "d6" designation signifies that the compound contains six deuterium atoms, which are isotopes of hydrogen, replacing the regular hydrogen atoms in the molecule. This modification is often utilized in research to trace metabolic pathways or to study the compound's behavior in biological systems. Desacetyl Diltiazem-d6 retains the core structure of diltiazem, which includes a benzothiazepine ring, and exhibits similar calcium channel blocking activity. Its unique isotopic labeling allows for enhanced analytical techniques, such as mass spectrometry, facilitating the study of its pharmacokinetics and dynamics. As with any chemical substance, safety and handling precautions should be observed, and its use should be guided by relevant regulatory standards.
Formula:C20H24N2O3S
InChI:InChI=1/C20H24N2O3S/c1-21(2)12-13-22-16-6-4-5-7-17(16)26-19(18(23)20(22)24)14-8-10-15(25-3)11-9-14/h4-11,18-19,23H,12-13H2,1-3H3/t18-,19+/s2/i1D3,2D3
InChI key:InChIKey=NZHUXMZTSSZXSB-WEAKZVRXNA-N
SMILES:C(CN(C([2H])([2H])[2H])C([2H])([2H])[2H])N1C=2C(S[C@H]([C@@H](O)C1=O)C3=CC=C(OC)C=C3)=CC=CC2
Synonyms:
  • Desacetyl Diltiazem-d6
  • Deacetyl-d-diltiazeM-d6
  • DeacetyldiltiazeM-d6
  • (2S-cis)-5-[(DiMethylaMino-d6)ethyl]-2,3-dihydro-3-hydroxy-2-(4-Methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • [2H6]-Desacetyl Diltiazem
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  • Desacetyl Diltiazem-d6
    TRC
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    Desacetyl Diltiazem-d6

    Controlled Product
    CAS:

    Applications A metabolite of labelled Diltiazem (D460620).
    References Shallcross, H., et al.: Br. Med. J., 295, 1236 (1987), Yeung, P.K.F., et al.: Drug Metab. Dispos., 18, 1055 (1990), Cashman, J.R., et al.: J. Med. Chem., 34,2049 (1991),

    Formula:C20H18D6N2O3S
    Color and Shape:Neat
    Molecular weight:378.52

    Ref: TR-D288688

    5mg
    240.00€
    50mg
    1,572.00€