CAS 1246833-26-0

Curcumin-d6

Description:

Curcumin-d6 is a deuterated form of curcumin, a natural polyphenolic compound derived from the rhizome of Curcuma longa, commonly known as turmeric. This compound is characterized by its vibrant yellow color and is known for its potential antioxidant, anti-inflammatory, and anticancer properties. The "d6" designation indicates that six hydrogen atoms in the molecule have been replaced with deuterium, a stable isotope of hydrogen, which enhances its utility in various analytical techniques, particularly in nuclear magnetic resonance (NMR) spectroscopy. Curcumin-d6 retains the core structural features of curcumin, including its diketone structure and phenolic groups, which contribute to its biological activity. It is often used in research to study the behavior of curcumin in biological systems, as the deuterated version can provide insights into metabolic pathways and interactions without interference from naturally occurring hydrogen. Overall, curcumin-d6 serves as a valuable tool in both medicinal chemistry and pharmacological studies.

Formula: C₂₁H₂₀O₆

InChI: InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/i1D3,2D3

InChI key: InChIKey=VFLDPWHFBUODDF-WFGJKAKNSA-N

SMILES: C(=CC(CC(C=CC1=CC(OC([2H])([2H])[2H])=C(O)C=C1)=O)=O)C2=CC(OC([2H])([2H])[2H])=C(O)C=C2

Synonyms:

• Turmeric yellow D6
• Natural Yellow 3 D6
• Diferuloylmethane D6
• Curcumin-d6
• Curcumin-d6 (dimethoxy-d6)
• [2H6]-Curcumin

Curcumin-d6 (dimethoxy-d6)

CAS: 1246833-26-0

Purity: 99 atom % D

Molecular weight: 374.42

Ref: 3U-D7916

Curcumin-d6

CAS: 1246833-26-0

Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-a

Formula: C₂₁H₂₀O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 374.422

Ref: TM-T10901

Curcumin-d6

Controlled Product

CAS: 1246833-26-0

Applications Labelled Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007),

Formula: C₂₁₂H₆H₁₄O₆

Color and Shape: Orange To Dark Orange

Molecular weight: 374.42

Ref: TR-C838502

Curcumin-d6

CAS: 1246833-26-0

Curcumin-d6 is a stable isotopic labeled compound, which is derived from the natural polyphenolic compound curcumin sourced from the plant Curcuma longa. As a deuterated analogue, its structure contains six deuterium atoms, which aid in various analytical applications. The mode of action for Curcumin-d6 involves providing a reference standard for mass spectrometry and nuclear magnetic resonance (NMR) studies, where its isotopic composition allows for precise, quantitative analysis and differentiation from non-labeled compounds.

Formula: C₂₁H₂₀O₆

Purity: Min. 95%

Molecular weight: 374.4 g/mol

Ref: 3D-WZB83326