CAS 124735-06-4

S-acetylthiorphan

Description:

S-acetylthiorphan is a chemical compound that functions primarily as a potent and selective inhibitor of the enzyme neprilysin, which plays a crucial role in the degradation of various neuropeptides and peptides involved in blood pressure regulation. This compound is characterized by its thiorphan backbone, which is modified by the addition of an acetyl group, enhancing its stability and bioavailability. S-acetylthiorphan has been studied for its potential therapeutic applications, particularly in the context of neurodegenerative diseases and conditions related to impaired peptide metabolism. The compound exhibits a relatively low molecular weight and is soluble in organic solvents, making it suitable for various biochemical assays. Its mechanism of action involves the inhibition of neprilysin, leading to increased levels of neuropeptides, which may have beneficial effects on neuronal health and function. Overall, S-acetylthiorphan represents a significant interest in pharmacological research, particularly in the fields of neurology and cardiovascular health.

Formula: C₁₄H₁₇NO₄S

InChI: InChI=1/C14H17NO4S/c1-10(16)20-9-12(14(19)15-8-13(17)18)7-11-5-3-2-4-6-11/h2-6,12H,7-9H2,1H3,(H,15,19)(H,17,18)

SMILES: CC(=O)SCC(Cc1ccccc1)C(=NCC(=O)O)O

Synonyms:

• Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, (+-)-
• Hemiacetorphan
• N-(2-((Acetylthio)methyl)-1-oxo-3-phenylpropyl)glycine
• S-Acetylthiophan
• N-[3-(acetylsulfanyl)-2-benzylpropanoyl]glycine
• S-Acetylthiorphan

S-Acetylthiorphan

CAS: 124735-06-4

Formula: C₁₄H₁₇NO₄S

Purity: 95%

Color and Shape: Solid

Molecular weight: 295.3541

Ref: IN-DA009E8E

Racecadotril EP Impurity C

CAS: 124735-06-4

Formula: C₁₄H₁₇NO₄S

Color and Shape: White To Off-White Solid

Molecular weight: 295.35

Ref: 4Z-R-731

Racecadotril Impurity 7

CAS: 124735-06-4

Formula: C₁₉H₂₀ClNO₃

Color and Shape: White To Off-White Solid

Molecular weight: 345.82

Ref: 4Z-R-7314

Hemiacetorphan

Controlled Product

CAS: 124735-06-4

Applications Hemiacetorphan is an impurity of Racecadotril (R070600), which is antidiarrheal, enkephalinase inhibitor, and also capable of reducing the amount of water and electrolytes into the intestine.
References Cezard, J., et al.: Gastroenterol., 120, 799 (2001), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Lakshmana, P., et al.: J. Pharm. Res., 8, 39 (2009),

Formula: C₁₄H₁₇NO₄S

Color and Shape: Neat

Molecular weight: 295.35

Ref: TR-H235105

Racecadotril EP Imurity C

CAS: 124735-06-4

Formula: C₁₄H₁₇NO₄S

Molecular weight: 295.35

Ref: ST-EA-CP-R21003