CAS 124750-92-1: Losartan carboxylic acid

Description: Losartan carboxylic acid, with the CAS number 124750-92-1, is a chemical compound that serves as an active metabolite of the antihypertensive drug losartan. It is characterized by its carboxylic acid functional group, which contributes to its solubility and reactivity. This compound is typically a white to off-white solid and is known for its role in the inhibition of the angiotensin II receptor, which is crucial in regulating blood pressure. Losartan carboxylic acid exhibits moderate lipophilicity, allowing it to interact effectively with biological membranes. Its pharmacological properties include vasodilation and the reduction of blood pressure, making it significant in the treatment of hypertension and related cardiovascular conditions. Additionally, it has a relatively low toxicity profile, which is advantageous for therapeutic applications. The compound is often studied for its pharmacokinetics and metabolic pathways, contributing to a better understanding of its efficacy and safety in clinical settings.

Formula: C₂₂H₂₁ClN₆O₂

InChI: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)

InChI key: InChIKey=ZEUXAIYYDDCIRX-UHFFFAOYSA-N

SMILES: O=C(O)C1=C(Cl)N=C(N1CC=2C=CC(=CC2)C=3C=CC=CC3C4=NN=NN4)CCCC

Synonyms:

• 1H-Imidazole-5-Carboxylicacid,2-Butyl-4-Chloro-1-((2'-(14-Tetrazol-5-Yl)(1,1
• 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
• 2-Butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
• 2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid
• Akos 91941
• E-3174
• Exp 3174
• Exp3174
• L-158641
• Losartan Carboxy Acid
• Losartan carboxylic acid

1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

CAS: 124750-92-1

• Formula: C₂₂H₂₁ClN₆O₂
• Purity: 97%
• Color and Shape: Solid
• Molecular weight: 436.8941

Losartan Carboxylic Acid

CAS: 124750-92-1

• Formula: C₂₂H₂₁ClN₆O₂
• Color and Shape: Pale Yellow To Brown Solid
• Molecular weight: 436.90

2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (Losartan Carboxylic Acid)

CAS: 124750-92-1

• Formula: C₂₂H₂₁ClN₆O₂
• Color and Shape: Neat
• Molecular weight: 436.89

Losartan Carboxylic Acid

CAS: 124750-92-1

Losartan Carboxylic Acid (E-3174) is a potent AT1 blocker with vasodilatory effects, stronger than losartan, …

• Formula: C₂₂H₂₁ClN₆O₂
• Purity: 98.36% - 99.28%
• Color and Shape: Light-Yellow Solid
• Molecular weight: 436.89

Losartan Carboxylic Acid

CAS: 124750-92-1

Applications A metabolite of Losartan. References Pieter, B.M.W.M., et al.: Hypertension, Supp. III, 18, 5, …

• Formula: C₂₂H₂₁ClN₆O₂
• Color and Shape: Neat
• Molecular weight: 436.89

Losartan carboxylic acid

CAS: 124750-92-1

Angiotensin II type 1 receptor antagonist

• Formula: C₂₂H₂₁ClN₆O₂
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 436.89 g/mol