CAS 124750-92-1

Losartan carboxylic acid

Description:

Losartan carboxylic acid, with the CAS number 124750-92-1, is a chemical compound that serves as an active metabolite of the antihypertensive drug losartan. It is characterized by its carboxylic acid functional group, which contributes to its solubility and reactivity. This compound is typically a white to off-white solid and is known for its role in the inhibition of the angiotensin II receptor, which is crucial in regulating blood pressure. Losartan carboxylic acid exhibits moderate lipophilicity, allowing it to interact effectively with biological membranes. Its pharmacological properties include vasodilation and the reduction of blood pressure, making it significant in the treatment of hypertension and related cardiovascular conditions. Additionally, it has a relatively low toxicity profile, which is advantageous for therapeutic applications. The compound is often studied for its pharmacokinetics and metabolic pathways, contributing to a better understanding of its efficacy and safety in clinical settings.

Formula: C₂₂H₂₁ClN₆O₂

InChI: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)

InChI key: InChIKey=ZEUXAIYYDDCIRX-UHFFFAOYSA-N

SMILES: C(N1C(CCCC)=NC(Cl)=C1C(O)=O)C2=CC=C(C=C2)C3=C(C=CC=C3)C=4NN=NN4

Synonyms:

• 1H-Imidazole-5-Carboxylicacid,2-Butyl-4-Chloro-1-((2'-(14-Tetrazol-5-Yl)(1,1
• 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 2-Butyl-4-chloro-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
• 2-Butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid
• 2-butyl-4-chloro-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid
• Akos 91941
• E-3174
• Exp 3174
• Exp3174
• L-158641
• Losartan Carboxy Acid

1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

CAS: 124750-92-1

Formula: C₂₂H₂₁ClN₆O₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 436.8941

Ref: IN-DA000MPU

Losartan Carboxylic Acid

CAS: 124750-92-1

Losartan Carboxylic Acid

Purity: 98%

Molecular weight: 436.89g/mol

Ref: 54-OR1026187

Losartan Carboxylic Acid

CAS: 124750-92-1

Losartan Carboxylic Acid

Purity: ≥98%

Molecular weight: 436.89g/mol

Ref: 54-BUP11166

Losartan Carboxylic Acid

CAS: 124750-92-1

Formula: C₂₂H₂₁ClN₆O₂

Color and Shape: Pale Yellow To Brown Solid

Molecular weight: 436.90

Ref: 4Z-L-112

2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (Losartan Carboxylic Acid)

CAS: 124750-92-1

Color and Shape: Neat

Ref: 86-MM0168.01

2-butyl-4-chloro-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylic acid

CAS: 124750-92-1

Purity: 97%

Molecular weight: 436.899993896484

Ref: 10-F861628

Losartan Carboxylic Acid

CAS: 124750-92-1

Losartan Carboxylic Acid (E-3174) is a potent AT1 blocker with vasodilatory effects, stronger than losartan, with Kis of 0.57 nM in rats and 0.67 nM in humans.

Formula: C₂₂H₂₁ClN₆O₂

Purity: 98.36% - 99.28%

Color and Shape: Light-Yellow Solid

Molecular weight: 436.89

Ref: TM-T3461

Losartan Carboxylic Acid

CAS: 124750-92-1

Formula: C₂₂H₂₁ClN₆O₂

Molecular weight: 436.90

Ref: ST-EA-CP-L25032

Losartan Carboxylic Acid

CAS: 124750-92-1

Applications A metabolite of Losartan.
References Pieter, B.M.W.M., et al.: Hypertension, Supp. III, 18, 5, (1991), Chang, L.L., et al.: J. Med. Chem., 36, 2558 (1993)

Formula: C₂₂H₂₁ClN₆O₂

Color and Shape: Neat

Molecular weight: 436.89

Ref: TR-L470510

Losartan carboxylic acid

CAS: 124750-92-1

Angiotensin II type 1 receptor antagonist

Formula: C₂₂H₂₁ClN₆O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 436.89 g/mol

Ref: 3D-FL24942