CAS 124752-25-6

6-aminocarbovir

Description:

6-Aminocarbovir is a synthetic nucleoside analog that has garnered attention in the field of medicinal chemistry, particularly for its potential antiviral properties. It is characterized by the presence of an amino group at the 6-position of the carbovir structure, which is a derivative of the naturally occurring nucleoside. This modification enhances its ability to inhibit viral replication, making it a candidate for treating viral infections, particularly those caused by retroviruses. The compound exhibits a polar nature due to the presence of the amino group, which influences its solubility and interaction with biological targets. Additionally, 6-aminocarbovir may demonstrate a favorable pharmacokinetic profile, although specific details regarding its absorption, distribution, metabolism, and excretion (ADME) properties would require further investigation. Its mechanism of action typically involves interference with viral RNA synthesis, positioning it as a valuable compound in antiviral drug development. As with many nucleoside analogs, the potential for resistance development in target viruses is an important consideration in its therapeutic application.

Formula: C₁₁H₁₄N₆O

InChI: InChI=1/C11H14N6O/c12-9-8-10(16-11(13)15-9)17(5-14-8)7-2-1-6(3-7)4-18/h1-2,5-7,18H,3-4H2,(H4,12,13,15,16)/t6-,7+/m1/s1

Synonyms:

• 2-Cyclopentene-1-methanol, 4-(2,6-diamino-9H-purin-9-yl)-, (1S-cis)-
• [(1S,4R)-4-(2,6-diamino-9H-purin-9-yl)cyclopent-2-en-1-yl]methanol
• 6-Aminocarbovir

Abacavir EP Impurity C

CAS: 124752-25-6

Formula: C₁₁H₁₄N₆O

Molecular weight: 246.27

Ref: 4Z-A-286

Abacavir Sulfate EP Impurity C (Abacavir Related USP Compound A)

Controlled Product

CAS: 124752-25-6

Formula: C₁₁H₁₄N₆O

Color and Shape: Neat

Molecular weight: 246.27

Ref: 86-MM3249.01

Descyclopropyl Abacavir

Controlled Product

CAS: 124752-25-6

Impurity Abacavir EP Impurity C; Abacavir USP Related Compound A
Applications Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Formula: C₁₁H₁₄N₆O

Color and Shape: Neat

Molecular weight: 246.27

Ref: TR-D288865

Descyclopropyl abacavir

CAS: 124752-25-6

Descyclopropyl abacavir is a synthetic prodrug form of the antiviral drug abacavir, which is used to treat HIV infection. It is metabolized by amine oxidases and, as such, has been shown to be a potent inhibitor of these enzymes. Descyclopropyl abacavir has also been shown to have herbicidal properties against control weeds and glyphosate-resistant weeds.

Formula: C₁₁H₁₄N₆O

Purity: Min. 95%

Molecular weight: 246.27 g/mol

Ref: 3D-FD21165

Abacavir EP Impurity C

CAS: 124752-25-6

Formula: C₁₁H₁₄N₆O

Molecular weight: 246.3

Ref: ST-EA-CP-A1003