CAS 124840-52-4

fluororaclopride

Description:

Fluororaclopride is a chemical compound that belongs to the class of substituted benzamides, primarily known for its application in the field of neuroscience as a radioligand for imaging dopamine D2 receptors. It is characterized by its high affinity and selectivity for these receptors, making it valuable in both research and clinical settings, particularly in studies related to neuropsychiatric disorders and drug addiction. The compound features a fluorine atom, which enhances its metabolic stability and improves its imaging properties. Fluororaclopride is typically administered in a radiolabeled form for positron emission tomography (PET) scans, allowing for non-invasive visualization of dopamine receptor distribution and density in the brain. Its chemical structure includes a raclopride backbone, modified with fluorine, which contributes to its pharmacological profile. Safety and handling precautions are essential due to its radioactive nature when used in imaging studies. Overall, fluororaclopride serves as a crucial tool in understanding the dopaminergic system and its implications in various neurological conditions.

Formula: C₁₅H₁₉Cl₂FN₂O₃

InChI: InChI=1/C15H19Cl2FN2O3/c1-23-14-11(17)7-10(16)13(21)12(14)15(22)19-8-9-3-2-5-20(9)6-4-18/h7,9,21H,2-6,8H2,1H3,(H,19,22)

SMILES: COc1c(cc(c(c1C(=NCC1CCCN1CCF)O)O)Cl)Cl

Synonyms:

• Ncq 258
• S-3,5-Dichloro-6-methoxy-N-(1-(2-(F-18)-fluoroethyl)-2-pyrrolidinylmethyl)salicylamide
• 3,5-dichloro-N-{[1-(2-fluoroethyl)pyrrolidin-2-yl]methyl}-2-hydroxy-6-methoxybenzamide
• Fluororaclopride