Calphostin I is a natural product derived from the fungus Calcarisporium arbuscula, known for its role as a potent protein kinase C (PKC) inhibitor. It exhibits a complex structure characterized by a polycyclic framework, which contributes to its biological activity. Calphostin I is primarily recognized for its ability to modulate cellular signaling pathways, making it a valuable tool in biochemical research, particularly in studies related to cancer and cell proliferation. The compound is typically used in laboratory settings to investigate the effects of PKC inhibition on various cellular processes. In terms of solubility, calphostin I is generally soluble in organic solvents, which facilitates its use in experimental applications. Its pharmacological properties and mechanism of action have made it a subject of interest in the development of therapeutic agents targeting diseases associated with dysregulated PKC activity. However, due to its potent biological effects, careful handling and consideration of safety protocols are essential when working with this compound.

The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides. The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.

calphostin I

124857-59-6: Calphostin I is a natural product derived from the fungus Calcarisporium arbuscula, known for its role as a potent protein kinase C (PKC) inhibitor. It exhibits a complex structure characterized by a polycyclic framework, which contributes to its biological activity. Calphostin I is primarily recognized for its ability to modulate cellular signaling pathways, making it a valuable tool in biochemical research, particularly in studies related to cancer and cell proliferation. The compound is typically used in laboratory settings to investigate the effects of PKC inhibition on various cellular processes. In terms of solubility, calphostin I is generally soluble in organic solvents, which facilitates its use in experimental applications. Its pharmacological properties and mechanism of action have made it a subject of interest in the development of therapeutic agents targeting diseases associated with dysregulated PKC activity. However, due to its potent biological effects, careful handling and consideration of safety protocols are essential when working with this compound.

Calphostins, from Cladosporium fungus, inhibit PKC. Notably, calphostin C is a potent biochemical tool.

CAS 124857-59-6

calphostin I

Calphostin I

Ref: TM-T71135