CAS 125-65-5

Pleuromutilin

Description:

Pleuromutilin is a natural antibiotic derived from the fungus *Pleurotus mutilus*. It belongs to the class of compounds known as pleuromutilins, which are characterized by their unique structure that includes a tetracyclic ring system. This antibiotic exhibits broad-spectrum activity against various Gram-positive bacteria and some Gram-negative bacteria, making it effective in treating infections caused by resistant strains. Pleuromutilin functions by inhibiting bacterial protein synthesis, specifically targeting the peptidyl transferase center of the ribosome, which disrupts the translation process. Its low toxicity profile and efficacy have led to its development for clinical use, particularly in treating skin and soft tissue infections. Additionally, pleuromutilin has been modified to create semisynthetic derivatives, such as retapamulin, which are used in topical formulations. The substance is typically administered in a controlled manner, and its pharmacokinetics are influenced by factors such as formulation and route of administration. Overall, pleuromutilin represents a significant advancement in antibiotic therapy, particularly in the face of rising antibiotic resistance.

Formula: C₂₂H₃₄O₅

InChI: InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13-,14+,16-,18+,19+,20-,21+,22+/m1/s1

InChI key: InChIKey=ZRZNJUXESFHSIO-BKUNHTPHSA-N

SMILES: C[C@@H]1[C@]23[C@]([C@](C)([C@H](OC(CO)=O)C[C@](C=C)(C)[C@H]1O)[C@H](C)CC2)(C(=O)CC3)[H]

Synonyms:

• (3aS,4R,5S,6S,8R,9S,9aR,10S)-6-ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate
• 14-Deoxy-14-[(hydroxyacetyl)oxy]mutilin
• 3a,9-Propano-3aH-cyclopentacyclooctene, acetic acid deriv.
• 6-Ethenyl-5-Hydroxy-4,6,9,10-Tetramethyl-1-Oxodecahydro-3A,9-Propanocyclopenta[8]Annulen-8-Yl Hydroxyacetate
• Acetic acid, 2-hydroxy-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, hydroxy-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Acetic acid, hydroxy-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester, [3aS-(3aα,4β,5α,6α,8β,9α,9aβ,10S*)]-
• Antibiotic A 40104C
• Bc 757
• Drosophilin B
• Glycolic acid, 8-ester with octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1(4H)-one
• Mutilin 14-glycolate
• NSC 121145

Pleuromutilin

CAS: 125-65-5

Purity: 98%

Color and Shape: Solid

Molecular weight: 378.509

Ref: 10-F987727

VALNEMULIN IMPURITY E CRS

CAS: 125-65-5

VALNEMULIN IMPURITY E CRS

Formula: C₂₂H₃₄O₅

Molecular weight: 378.5024

Ref: 41-Y0000586

Acetic acid, hydroxy-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Purity: 90%

Color and Shape: Solid

Molecular weight: 378.5024

Ref: IN-DA00HHVG

Pleuromutilin

CAS: 125-65-5

Pleuromutilin

Purity: ≥98%

Molecular weight: 378.5g/mol

Ref: 54-BUP14420

Tiamulin EP Impurity G (Valnemulin EP Impurity E)

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Molecular weight: 378.51

Ref: 4Z-T-9410

Pleuromutilin

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Purity: ≥ 95.0%

Color and Shape: White to off-white or light yellow solid

Molecular weight: 378.5

Ref: 7W-GA2930

(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-Ethenyl-5-hydroxy-4,6,9,10-tetramethyl-1-oxodecahydro-3a,9-propano-3aH-cyclopentacycloocten-8-yl Hydroxyacetate (Pleuromutilin)

Controlled Product

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Color and Shape: Neat

Molecular weight: 378.50

Ref: 86-MM0394.10

Pleuromutilin

CAS: 125-65-5

Pleuromutilin (Drosophilin B) is an inhibitor of bacterial protein synthesis by binding to the 50S ribosomal subunit of bacteria.

Formula: C₂₂H₃₄O₅

Purity: 97.321%

Color and Shape: Crystalline Solid

Molecular weight: 378.5

Ref: TM-T16552

Pleuromutilin

Controlled Product

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Color and Shape: Neat

Molecular weight: 378.50

Ref: TR-P610500

Pleuromulin

CAS: 125-65-5

The compound 5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate is an antimicrobial agent that inhibits bacterial growth by binding to the disulfide bond of bacterial peptidoglycan. It is effective against a wide range of microorganisms including MRSA and methicillin resistant Enterococcus faecalis. The compound has shown efficacy in an animal model of chronic bronchitis caused by Streptococcus pneumoniae. The compound has a short half life and can be administered orally or intravenously with a pharmacokinetic profile that depends on the dose. This drug also has high resistance to β lactamase enzymes, which are found in some bacteria such as E. coli.

Formula: C₂₂H₃₄O₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 378.5 g/mol

Ref: 3D-FP27100

Pleuromulin - Bio-X ™

CAS: 125-65-5

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₂H₃₄O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 378.5 g/mol

Ref: 3D-BH300113

Tiamulin EP Impurity G

CAS: 125-65-5

Formula: C₂₂H₃₄O₅

Molecular weight: 378.51

Ref: ST-EA-CP-T154005