CAS 125-71-3

Dextromethorphan

Description:

Dextromethorphan (DXM) is a synthetic morphinan derivative primarily used as a cough suppressant in over-the-counter medications. It is classified as a non-opioid antitussive agent, meaning it alleviates coughing without the addictive properties associated with opioids. DXM acts on the central nervous system, specifically targeting the sigma-1 receptor and the NMDA receptor, which contributes to its cough-suppressing effects. The substance is typically administered in various formulations, including syrups, tablets, and lozenges. Dextromethorphan is generally well-tolerated, but it can cause side effects such as dizziness, nausea, and drowsiness. At higher doses, it may produce dissociative effects similar to those of hallucinogens, leading to its potential for misuse. The chemical structure of DXM includes a methoxy group, which distinguishes it from other morphinans. Its CAS number, 125-71-3, is a unique identifier used for regulatory and safety purposes. Overall, while DXM is effective for treating cough, it should be used responsibly to avoid adverse effects and potential misuse.

Formula: C₁₈H₂₅NO

InChI: InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1

InChI key: InChIKey=MKXZASYAUGDDCJ-NJAFHUGGSA-N

SMILES: O(C)C=1C=C2[C@]34[C@@]([C@](CC2=CC1)(N(C)CC3)[H])(CCCC4)[H]

Synonyms:

• (+)-3-Methoxy-17-methylmorphinan
• (+)-3-methoxy-N-methylmorphinan
• (+)-cis-1,3,4,9,10,10a-hexahydro-6-methoxy-11-methyl-2H-10,4a-iminoethanophenanthrene
• (14Α)-3-Methoxy-17-Methylmorphinan
• (9α,13α,14α)-3-Methoxy-17-methylmorphinan
• 3-Methoxy-17-Methyl-(9Alpha,13Alpha,14Alpha)-Morphinan
• 3-Methoxy-17-methyl-9α,13α,14α-morphinan
• 9α,13α,14α-Morphinan, 3-methoxy-17-methyl-
• Ba 2666
• Benylin DM
• D-1,2,3,9,10,10a-Hexahydro-6-methoxy-11-methyl-4H-10,4a-iminoethanophenanthrene
• D-3-Methoxy-N-methylmorphinan
• DEX
• DXM
• DXM Free Base
• Dextromethorphane
• Dextrometorfano
• Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-
• Nodex
• Romilar CF
• d-Methorphan

Dextromethorphan

CAS: 125-71-3

Color and Shape: Neat

Ref: LP-DEX-873-FB-10

Dextromethorphan, 1mg/ml in Methanol

CAS: 125-71-3

Color and Shape: Single Solution

Ref: LP-DEX-873-FB-1LM

Dextromethorphan

CAS: 125-71-3

Drugs containing a quinoline or isoquinoline ring-system (whether or not hydrogenated) not further fused

Formula: C₁₈H₂₅NO

Color and Shape: White Light Yellow Powder

Molecular weight: 271.19361

Ref: 45-1180503

Dextromethorphan

CAS: 125-71-3

Applications Dextromethorphan is an antitussive compound showing analgesic properties. Used in cough medication formulations.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Church J. et al.: Can J Physiol Pharmacol., 67, 561 (1989); Carliss, R. et al.: Neurotoxicology., 28, 813 (2007);

Formula: C₁₈H₂₅NO

Color and Shape: Neat

Molecular weight: 271.40

Ref: TR-D299445

N-Nitroso Dextromethorphan

Controlled Product

CAS: 125-71-3

Applications N-Nitroso Dextromethorphan is an impurity of Dextromethorphan (D299445). Dextromethorphan is an antitussive compound showing analgesic properties. Used in cough medication formulations.
References Church J. et al.: Can J Physiol Pharmacol., 67, 561 (1989); Carliss, R. et al.: Neurotoxicology., 28, 813 (2007);

Formula: C₁₇H₂₂N₂O₂

Color and Shape: Light Yellow

Molecular weight: 286.369

Ref: TR-N839350

Dextromethorphan

Controlled Product

CAS: 125-71-3

9-alpha,-14-alpha-3-Methoxy-17-methylmorphinan (914) is a drug that is used in the treatment of bowel disease. It has been shown to inhibit the activity of enzymes such as polymerase chain, which is responsible for DNA replication and repair. 914 also inhibits dextromethorphan, an opioid that is used in cough suppressant medications. The effects of 914 on dextromethorphan are seen in human subjects who have been given the drug intravenously or orally. 914 binds to receptors that are found on cells in the brain and spinal cord, which explains its analgesic properties. This drug can be dangerous when taken with nonsteroidal anti-inflammatory drugs because it can cause kidney damage or failure.

Formula: C₁₈H₂₅NO

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 271.4 g/mol

Ref: 3D-FM36326

Compound T0262L2(SC)

CAS: 125-71-3

Dextromethorphan is a noncompetitive NMDA receptor antagonist and sigma-1 agonist that was approved by the FDA in 1958 for use as a cough suppressant.Cost-effective and quality-assured.

Formula: C₁₈H₂₅NO

Purity: 99.88%

Color and Shape: White To Slightly Yellow Crystalline Powder Solid

Molecular weight: 271.3972

Ref: TM-T0262L2

Morphinan, 3-methoxy-17-methyl-, (9α,13α,14α)-

CAS: 125-71-3

Formula: C₁₈H₂₅NO

Color and Shape: Solid

Molecular weight: 271.3972

Ref: IN-DA000MZ9