CAS 125155-51-3

2-DEOXY-2-FLUORO-D-ARABINOFURANOSE

Description:

2-Deoxy-2-fluoro-D-arabinofuranose is a modified sugar that belongs to the class of nucleoside analogs. It is characterized by the presence of a fluorine atom at the second carbon position of the arabinofuranose ring, replacing a hydroxyl group found in its natural counterpart, D-arabinofuranose. This modification can influence the compound's biological activity, particularly in the context of nucleic acid synthesis and antiviral properties. The presence of the fluorine atom enhances the stability of the sugar, making it resistant to enzymatic degradation. This compound is of interest in medicinal chemistry and biochemistry, particularly for its potential applications in antiviral drug development and as a building block for nucleoside analogs. Its structural features include a five-membered furanose ring and a specific stereochemistry that is crucial for its interaction with biological targets. Overall, 2-deoxy-2-fluoro-D-arabinofuranose serves as an important tool in research and therapeutic applications, particularly in the fields of virology and cancer treatment.

Formula: C₅H₉FO₄

Synonyms:

• 2-Fluoro-2-Deoxy-D-Arabinose
• 2-DEOXY-2-FLUORO-D-ARABINOFURANOSE

2-Fluoro-2-deoxy-D-arabinose

CAS: 125155-51-3

Formula: C₅H₉FO₄

Molecular weight: 152.1210

Ref: IN-DA000N99

2-Deoxy-2-fluoro-D-arabinofuranose

CAS: 125155-51-3

Ref: 7W-GC8283

2-Deoxy-2-fluoro-D-arabinofuranose

CAS: 125155-51-3

2-Deoxy-2-fluoro-D-arabinofuranose is a purine nucleoside that is used in the diagnosis and treatment of herpes simplex virus infection. It inhibits viral replication by competitively inhibiting acycloguanosine, an enzyme that catalyzes the conversion of 2’-deoxyguanosine to deoxyadenosine. 2-Deoxy-2-fluoro-D-arabinofuranose has been shown to be active against cancer cells and can be used as chemotherapeutic agent. This drug may also be used for the diagnosis of cancer by detecting the presence of activated T cells in patients with tumor necrosis factor α (TNFα) receptor gene polymorphism.

Formula: C₅H₉FO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 152.12 g/mol

Ref: 3D-MD06006

2-Deoxy-2-fluoro-D-arabinofuranose

Controlled Product

CAS: 125155-51-3

Applications 2-Deoxy-2-fluoro-D-arabinofuranose is a useful intermediate in the polymerase-directed synthesis of 2'-deoxy-2'-fluoro-β-D-arabinonucleic acids.
References Peng, C. G., et al.: J. Am. Chem. Soc., 129, 5310 (2007)

Formula: C₅H₉FO₄

Color and Shape: Neat

Molecular weight: 152.121

Ref: TR-D239980