CAS 1252003-15-8

Tubastatin A

Description:

Tubastatin A is a small molecule inhibitor primarily known for its role as a selective inhibitor of histone deacetylase 6 (HDAC6). This compound is characterized by its ability to modulate the acetylation status of proteins, which plays a crucial role in various cellular processes, including gene expression, cell cycle regulation, and apoptosis. Tubastatin A has garnered attention in the field of cancer research due to its potential therapeutic effects, particularly in enhancing the efficacy of other anticancer agents and in the treatment of neurodegenerative diseases. The compound exhibits a relatively high selectivity for HDAC6 over other histone deacetylases, which may contribute to its reduced side effects compared to non-selective HDAC inhibitors. Additionally, Tubastatin A has been studied for its impact on cellular pathways involved in protein degradation and stress responses, making it a valuable tool in both basic research and potential clinical applications. Its unique chemical structure and mechanism of action continue to be explored for further therapeutic implications.

Formula: C₂₀H₂₁N₃O₂

InChI: InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)

InChI key: InChIKey=GOVYBPLHWIEHEJ-UHFFFAOYSA-N

SMILES: C(N1C2=C(C=3C1=CC=CC3)CN(C)CC2)C4=CC=C(C(NO)=O)C=C4

Synonyms:

• Benzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-
• N-Hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
• Tubastatin A
• N-hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3-b]indol-5-ylmethyl)benzamide
• Tubastatin A(free base)
• Tubastatin A BASE
• N-hydroxy-4-((2-methyl-2,3,4,5-tetrahydro-1H-indeno[1,2-c]pyridin-5-yl)methyl)benzamide
• N-hydroxy-4-((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)methyl)benzamide
• CS-1922
• N-Hydroxy-4-[(2-methyl-1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indol-5 -yl)methyl]benzamide
• Tubastatin

Tubastatin-A

CAS: 1252003-15-8

Formula: C₂₀H₂₁N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 335.3996

Ref: IN-DA009BPD

Tubastatin A

CAS: 1252003-15-8

Tubastatin A

Purity: ≥95%

Molecular weight: 335.4g/mol

Ref: 54-BUP15674

Tubastatin A

CAS: 1252003-15-8

Ref: 7W-GW9504

Tubastatin A

CAS: 1252003-15-8

Tubastatin A: Selective HDAC6 inhibitor, IC50 of 15 nM, 1000x less effective on other isozymes except HDAC8.

Formula: C₂₀H₂₁N₃O₂

Purity: 97.22% - 99.51%

Color and Shape: Solid

Molecular weight: 335.4

Ref: TM-T1966

Tubastatin A

CAS: 1252003-15-8

Purity: 98%

Molecular weight: 335.4070129

Ref: 10-F951535