6-Carboxy Simvastatin, identified by the CAS number 125206-31-7, is a derivative of Simvastatin, which is a well-known statin used primarily for lowering cholesterol levels in the blood. This compound features a carboxylic acid functional group, which enhances its solubility and bioavailability compared to its parent compound. The presence of the carboxylic acid group also influences its pharmacokinetic properties, potentially affecting its metabolism and excretion. Like other statins, 6-Carboxy Simvastatin functions by inhibiting HMG-CoA reductase, an enzyme critical in the cholesterol biosynthesis pathway. This inhibition leads to a decrease in cholesterol production in the liver, resulting in lower levels of LDL cholesterol in the bloodstream. The compound may also exhibit anti-inflammatory properties and has been studied for its potential effects on cardiovascular health. Overall, 6-Carboxy Simvastatin represents an important modification of Simvastatin, contributing to the ongoing research into statin efficacy and safety profiles.

6Carboxy Simvastatin

125206-31-7: 6-Carboxy Simvastatin, identified by the CAS number 125206-31-7, is a derivative of Simvastatin, which is a well-known statin used primarily for lowering cholesterol levels in the blood. This compound features a carboxylic acid functional group, which enhances its solubility and bioavailability compared to its parent compound. The presence of the carboxylic acid group also influences its pharmacokinetic properties, potentially affecting its metabolism and excretion. Like other statins, 6-Carboxy Simvastatin functions by inhibiting HMG-CoA reductase, an enzyme critical in the cholesterol biosynthesis pathway. This inhibition leads to a decrease in cholesterol production in the liver, resulting in lower levels of LDL cholesterol in the bloodstream. The compound may also exhibit anti-inflammatory properties and has been studied for its potential effects on cardiovascular health. Overall, 6-Carboxy Simvastatin represents an important modification of Simvastatin, contributing to the ongoing research into statin efficacy and safety profiles.

2-Naphthalenecarboxylic acid, 4-(2,2-dimethyl-1-oxobutoxy)-3,4,4a,5,6,7-hexahydro-6-methyl-5-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-, [4S-[4α,4aβ,5β(2S*,4S*),6β]]- (9CI)

CAS 125206-31-7

6Carboxy Simvastatin

2-Naphthalenecarboxylic acid, 4-(2,2-dimethyl-1-oxobutoxy)-3,4,4a,5,6,7-hexahydro-6-methyl-5-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-, [4S-[4α,4aβ,5β(2S,4S),6β]]- (9CI)

Ref: IN-DA000ND1