CAS 125258-62-0

1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-5-methyl-2(1H)-pyrimidinone

Description:

The chemical substance known as "1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-5-methyl-2(1H)-pyrimidinone" with CAS number 125258-62-0 is a complex organic compound characterized by its intricate molecular structure, which includes multiple functional groups such as pyrimidinone, phosphino, and various aromatic moieties. This compound is likely to exhibit significant biological activity due to its structural features, which may interact with biological targets. The presence of methoxy groups suggests potential for enhanced lipophilicity, while the phosphino group may confer unique reactivity or binding properties. Additionally, the sugar moiety indicates that it may have nucleoside-like characteristics, potentially influencing its pharmacological profile. Overall, this compound's complexity and functional diversity make it a subject of interest in medicinal chemistry and drug development, although specific biological activities and applications would require further investigation.

Formula: C₄₀H₄₉N₄O₇P

InChI: InChI=1S/C40H49N4O7P/c1-28(2)44(29(3)4)52(49-23-11-22-41)51-36-24-38(43-26-30(5)25-42-39(43)45)50-37(36)27-48-40(31-12-9-8-10-13-31,32-14-18-34(46-6)19-15-32)33-16-20-35(47-7)21-17-33/h8-10,12-21,25-26,28-29,36-38H,11,23-24,27H2,1-7H3/t36-,37+,38+,52?/m0/s1

InChI key: InChIKey=IVZVCEADSAZPGG-VAVRNPHNSA-N

SMILES: C(OC[C@@H]1[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)C[C@@H](O1)N2C(=O)N=CC(C)=C2)(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5

Synonyms:

• 2(1H)-Pyrimidinone, 1-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-5-methyl-
• 1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-deoxy-β-D-erythro-pentofuranosyl]-5-methyl-2(1H)-pyrimidinone

2''-Deoxy-5''-O-DMT-5-methylzebularine 3''-CE phosphoramidite

CAS: 125258-62-0

Ref: 7W-GN4066

2'-Deoxy-5'-O-DMT-5-methylzebularine 3'-CE phosphoramidite

CAS: 125258-62-0

2'-Deoxy-5'-O-DMT-5-methylzebularine 3'-CE phosphoramidite is a novel nucleoside that has been modified to contain a 5-methyl group at the 2′ position. It is phosphorylated with a phosphate group at the 3′ position and linked to an oligonucleotide via a 3′-O,O′-dimethoxytrityl (DMT) spacer. This novel nucleoside has antiviral activity against hepatitis C virus and cytomegalovirus, as well as anticancer properties. 2'-Deoxy-5'-O-DMT-5-methylzebularine 3'-CE phosphoramidite has shown antitumour activity in animal models of human breast cancer and melanoma.

Formula: C₄₀H₄₉N₄O₇P

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 728.81 g/mol

Ref: 3D-PD09127