CymitQuimica logo

CAS 125314-64-9

:

Bisindolylmaleimide IX

Description:
Bisindolylmaleimide IX, with the CAS number 125314-64-9, is a synthetic compound that belongs to the class of indole derivatives and is known for its role as a selective inhibitor of protein kinase C (PKC). This compound features a bisindole structure linked to a maleimide moiety, which contributes to its biological activity. It is characterized by its ability to modulate various cellular processes, including cell proliferation and differentiation, making it of interest in cancer research and other therapeutic applications. Bisindolylmaleimide IX is typically a solid at room temperature and is soluble in organic solvents. Its mechanism of action involves the inhibition of PKC isoforms, which play critical roles in signal transduction pathways. This compound is often utilized in biochemical assays and pharmacological studies to explore the functions of PKC in various cellular contexts. Safety and handling precautions should be observed, as with any chemical substance, due to potential toxicity and reactivity.
Formula:C25H23N5O2S
InChI:InChI=1/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4)
InChI key:InChIKey=DSXXEELGXBCYNQ-UHFFFAOYSA-N
SMILES:O=C1C(C=2C=3C(N(CCCSC(=N)N)C2)=CC=CC3)=C(C(=O)N1)C=4C=5C(N(C)C4)=CC=CC5
Synonyms:
  • Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester
  • Ro 31-8220
  • Ro 318220
  • Bisindolylmaleimide IX
  • Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1)
  • 3-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate methanesulfonate
  • 3-{3-[4-(1-Methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-1-yl}propyl carbamimidothioate methanesulfonate (1:1)
  • Ro 31-8220 methanesulfonate salt
  • 3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE METHANESULFONATE
  • 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate salt
  • See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 3 products.
  • Ro 31-8220
    Indagoo
    + Info

    Ro 31-8220

    CAS:
    Formula:C25H23N5O2S
    Molecular weight:457.5474

    Ref: IN-DA000NHG

    ne
    To inquire
  • Ro 31-8220
    Targetmol
    + Info

    Ro 31-8220

    CAS:
    <p>Ro 31-8220: potent PKC inhibitor (IC50: 5-27 nM). Affects MAPKAP-K1b, MSK1, S6K1, GSK3β (IC50: 3-38 nM), not MKK3/4/6/7.</p>
    Formula:C25H23N5O2S
    Color and Shape:Solid
    Molecular weight:457.55

    Ref: TM-T6643L

  • Bisindolylmaleimide IX
    Biosynth
    + Info

    Bisindolylmaleimide IX

    CAS:
    <p>Bisindolylmaleimide IX is a small molecule that inhibits protein kinase C (PKC) and has been shown to be useful in the treatment of bowel disease. Bisindolylmaleimide IX also induces apoptosis by binding to the pro-apoptotic protein Bax, which leads to the release of cytochrome c from mitochondria and activation of caspases. This drug plays an important role in regulating cell proliferation, differentiation, and apoptosis. It binds to basic proteins such as albumin and other serum proteins, making it difficult for bisindolylmaleimide IX to enter cells. However, this compound has been shown to inhibit the activity of drug transporters such as P-glycoprotein, which may enhance its penetration into cancer cells.</p>
    Formula:C25H23N5O2S
    Purity:Min. 95%
    Molecular weight:457.5 g/mol

    Ref: 3D-AFA31464

    25mg
    757.00€
    50mg
    1,142.00€
    100mg
    1,588.00€