CAS 125317-39-7: Navelbine
Description:Navelbine, known by its generic name vinorelbine, is a semi-synthetic vinca alkaloid derived from the periwinkle plant, Catharanthus roseus. It is primarily used as a chemotherapeutic agent in the treatment of various cancers, including non-small cell lung cancer and breast cancer. Vinorelbine functions by inhibiting microtubule formation during cell division, thereby disrupting the mitotic spindle and leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. The compound is typically administered intravenously and has a moderate side effect profile, which may include neutropenia, nausea, and fatigue. Its pharmacokinetics involve hepatic metabolism, primarily through the cytochrome P450 system, and it is excreted mainly in the bile. The CAS number 125317-39-7 uniquely identifies vinorelbine in chemical databases, facilitating research and clinical applications. Overall, Navelbine represents an important therapeutic option in oncology, contributing to improved outcomes in patients with specific malignancies.
Formula:C45H54N4O8·2C4H6O6
InChI:InChI=1S/C45H54N4O8.C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;1-2,5-6H,(H,7,8)(H,9,10)/t28-,37-,38+,39+,42+,43+,44-,45-;1-,2-/m01/s1
InChI key:InChIKey=UUHYRRXICWUZHW-RPZOAHRESA-N
SMILES:O=C(O)C(O)C(O)C(=O)O.O=C(OC1C(O)(C(=O)OC)C2N(C3=CC(OC)=C(C=C3C42CCN5CC=CC1(CC)C54)C6(C(=O)OC)C=7NC=8C=CC=CC8C7CN9CC(=CC(C9)C6)CC)C)C
- Synonyms:
- (3Ar,3A1R,4R,5S,5Ar,10Br)-Methyl 4-Acetoxy-3A-Ethyl-9-((2S,6S,8S)-4-Ethyl-8-(Methoxycarbonyl)-1,3,6,7,8,9-Hexahydro-2,6-Methanoazecino[4,3-B]Indol-8-Yl)-5-Hydroxy-8-Methoxy-6-Methyl-3A,3A1,4,5,5A,6,11
- 3',4'-Didehydro-4'-Deoxy-C'-Norvincaleukoblastine
- 3',4'-didehydro-4'-deoxy-c'-norvincaleukoblastine R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt
- 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine tartrate
- 5'-Noranhydrovinoblastine Tartrate
- Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
- Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
- Bitartrate
- Butanedioate(1:2)
- C'-norvincaleukoblastine,3',4'-didehydro-4'-dioxy-,(R-(R*,R*))-2,3-dihydroxy
- See more synonyms
- C′-Norvincaleukoblastine, 3′,4′-didehydro-4′-deoxy-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt)
- Kw 2307
- Navelbine
- Navelbine ditartrate
- Navelbine tartrate
- Nor-5′-anhydrovinblastine ditartrate
- Nvb
- Pacilitaxel
- Vinorelbin
- Vinorelbine bitartrate
- Vinorelbine bitratrate
- Vinorelbine ditartaric acid
- Vinorelbine ditartrate salt
- Vinorelbine tartarate
- Vinorelbine tartrate
- Vinorelbine tartrate usp standard
- Vinorelbineditartrate salt hydrate
- [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt]
- methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
- methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
- methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
- Vinorelbine ditartrate