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Navelbine

CAS 125317-39-7: Navelbine

Description:Navelbine, known by its generic name vinorelbine, is a semi-synthetic vinca alkaloid derived from the periwinkle plant, Catharanthus roseus. It is primarily used as a chemotherapeutic agent in the treatment of various cancers, including non-small cell lung cancer and breast cancer. Vinorelbine functions by inhibiting microtubule formation during cell division, thereby disrupting the mitotic spindle and leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. The compound is typically administered intravenously and has a moderate side effect profile, which may include neutropenia, nausea, and fatigue. Its pharmacokinetics involve hepatic metabolism, primarily through the cytochrome P450 system, and it is excreted mainly in the bile. The CAS number 125317-39-7 uniquely identifies vinorelbine in chemical databases, facilitating research and clinical applications. Overall, Navelbine represents an important therapeutic option in oncology, contributing to improved outcomes in patients with specific malignancies.

Formula:C45H54N4O8·2C4H6O6

InChI:InChI=1S/C45H54N4O8.C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;1-2,5-6H,(H,7,8)(H,9,10)/t28-,37-,38+,39+,42+,43+,44-,45-;1-,2-/m01/s1

InChI key:InChIKey=UUHYRRXICWUZHW-RPZOAHRESA-N

SMILES:O=C(O)C(O)C(O)C(=O)O.O=C(OC1C(O)(C(=O)OC)C2N(C3=CC(OC)=C(C=C3C42CCN5CC=CC1(CC)C54)C6(C(=O)OC)C=7NC=8C=CC=CC8C7CN9CC(=CC(C9)C6)CC)C)C

  • Synonyms:
  • (3Ar,3A1R,4R,5S,5Ar,10Br)-Methyl 4-Acetoxy-3A-Ethyl-9-((2S,6S,8S)-4-Ethyl-8-(Methoxycarbonyl)-1,3,6,7,8,9-Hexahydro-2,6-Methanoazecino[4,3-B]Indol-8-Yl)-5-Hydroxy-8-Methoxy-6-Methyl-3A,3A1,4,5,5A,6,11
  • 3',4'-Didehydro-4'-Deoxy-C'-Norvincaleukoblastine
  • 3',4'-didehydro-4'-deoxy-c'-norvincaleukoblastine R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt
  • 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine tartrate
  • 5'-Noranhydrovinoblastine Tartrate
  • Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
  • Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
  • Bitartrate
  • Butanedioate(1:2)
  • C'-norvincaleukoblastine,3',4'-didehydro-4'-dioxy-,(R-(R*,R*))-2,3-dihydroxy
  • See more synonyms
  • C′-Norvincaleukoblastine, 3′,4′-didehydro-4′-deoxy-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt)
  • Kw 2307
  • Navelbine
  • Navelbine ditartrate
  • Navelbine tartrate
  • Nor-5′-anhydrovinblastine ditartrate
  • Nvb
  • Pacilitaxel
  • Vinorelbin
  • Vinorelbine bitartrate
  • Vinorelbine bitratrate
  • Vinorelbine ditartaric acid
  • Vinorelbine ditartrate salt
  • Vinorelbine tartarate
  • Vinorelbine tartrate
  • Vinorelbine tartrate usp standard
  • Vinorelbineditartrate salt hydrate
  • [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt]
  • methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
  • methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
  • methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
  • Vinorelbine ditartrate
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Found 18 products.

BrandProduct dataPurityPrice rangeEstimated delivery
Acros logo
Vinorelbine tartrate, 98%
REF: AC-46198
CAS: 125317-39-7
98%To inquireMon 03 Mar 25
EDQM - European Pharmacopoeia logo
Vinorelbine tartrate CRS
REF: 41-Y0000463
CAS: 125317-39-7
- - -115.00 €Mon 03 Mar 25
EDQM - European Pharmacopoeia logo
Vinorelbine for peak identification A CRS
REF: 41-Y0001938
CAS: 125317-39-7
- - -115.00 €Mon 03 Mar 25
EDQM - European Pharmacopoeia logo
Vinorelbine for peak identification B CRS
REF: 41-Y0001939
CAS: 125317-39-7
- - -115.00 €Mon 03 Mar 25
USP logo
Vinorelbine Tartrate
REF: 45-1714506
CAS: 125317-39-7
- - -4,011.00 €Tue 04 Mar 25
Indagoo logo
Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2b,3b,4b,5a,12R,19a)-,(2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
REF: IN-DA00HI66
CAS: 125317-39-7
- - -To inquireWed 05 Mar 25
Apollo Scientific logo
Vinorelbine Ditartrate Salt
REF: 54-BIFK0008
CAS: 125317-39-7
98%134.00 €~368.00 €Thu 06 Mar 25
TLC logo
Vinorelbine Ditartrate
REF: 4Z-V-040001
CAS: 125317-39-7
- - -To inquireThu 06 Mar 25
Mikromol logo
Vinorelbine Tartrate
REF: 86-MM1252.00
CAS: 125317-39-7
- - -298.00 €Mon 10 Mar 25
Doctor Ehrenstorfer logo
Vinorelbine tartrate
REF: 04-CA17921850
CAS: 125317-39-7
- - -91.00 €Mon 10 Mar 25
Biopurify logo
Vinorelbine Tartrate
REF: BP-BP1446
CAS: 125317-39-7
95%~99%40.00 €~441.00 €Mon 10 Mar 25
TCI logo
Vinorelbine Ditartrate
REF: 3B-V0151
CAS: 125317-39-7
>95.0%(T)(HPLC)384.00 €Mon 10 Mar 25
Targetmol logo
Vinorelbine ditartrate
REF: TM-T6213
CAS: 125317-39-7
98% - 99.86%35.00 €~653.00 €Wed 12 Mar 25
Glentham logo
Vinorelbine ditartrate
REF: 7W-GP5205
CAS: 125317-39-7
(HPLC) ≥ 98.0% (dried basis)56.00 €~243.00 €Wed 12 Mar 25
TRC logo
Vinorelbine Bitartrate
REF: TR-V315000
CAS: 125317-39-7
- - -205.00 €~716.00 €Mon 17 Mar 25
TRC logo
Vinorelbine-d3 Bitartrate
REF: TR-V315002
CAS: 125317-39-7
- - -527.00 €~3,648.00 €Mon 17 Mar 25
Biosynth logo
Vinorelbine tartrate - Bio-X ™
REF: 3D-BV300138
CAS: 125317-39-7
Min. 95%147.00 €Tue 18 Mar 25
Biosynth logo
Vinorelbine tartrate
REF: 3D-FV61484
CAS: 125317-39-7
(Hplc) Min. 98.0%78.00 €~1,252.00 €Tue 18 Mar 25
discount label

Vinorelbine tartrate, 98%

CAS:125317-39-7

Ref: AC-46198

25mgTo inquire
100mg441.00 €
Estimated delivery in United States, on Monday 3 Mar 2025
discount label

Ref: 41-Y0000463

50mg115.00 €
Estimated delivery in United States, on Monday 3 Mar 2025
discount label

Vinorelbine Tartrate

CAS:125317-39-7

Ref: 45-1714506

200mg4,011.00 €
Estimated delivery in United States, on Tuesday 4 Mar 2025
discount label

Vinorelbine Ditartrate Salt

CAS:125317-39-7

Ref: 54-BIFK0008

10mg134.00 €
25mg220.00 €
50mg368.00 €
Estimated delivery in United States, on Thursday 6 Mar 2025
discount label

Vinorelbine Ditartrate

CAS:125317-39-7

Ref: 4Z-V-040001

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Thursday 6 Mar 2025
discount label

Vinorelbine Tartrate

Controlled Product
CAS:125317-39-7

Ref: 86-MM1252.00

100mg298.00 €
Estimated delivery in United States, on Monday 10 Mar 2025
discount label

Vinorelbine tartrate

CAS:125317-39-7

Ref: 04-CA17921850

10mg91.00 €
Estimated delivery in United States, on Monday 10 Mar 2025
discount label

Vinorelbine Tartrate

CAS:125317-39-7

Ref: BP-BP1446

20mg40.00 €
100mg104.00 €
1000mg441.00 €
Estimated delivery in United States, on Monday 10 Mar 2025
discount label

Ref: 3B-V0151

100mg384.00 €
Estimated delivery in United States, on Monday 10 Mar 2025
discount label

Vinorelbine ditartrate

CAS:125317-39-7

Ref: TM-T6213

5mg35.00 €
10mg56.00 €
25mg106.00 €
50mg173.00 €
100mg274.00 €
500mg653.00 €
1mL*10mM (DMSO)66.00 €
Estimated delivery in United States, on Wednesday 12 Mar 2025
discount label

Vinorelbine ditartrate

CAS:125317-39-7

Ref: 7W-GP5205

5mg56.00 €
10mg79.00 €
25mg138.00 €
50mg243.00 €
Estimated delivery in United States, on Wednesday 12 Mar 2025
discount label

Vinorelbine Bitartrate

Controlled Product
CAS:125317-39-7

Ref: TR-V315000

10mg205.00 €
25mg367.00 €
100mg716.00 €
Estimated delivery in United States, on Monday 17 Mar 2025
discount label

Vinorelbine-d3 Bitartrate

Controlled Product
CAS:125317-39-7

Ref: TR-V315002

1mg527.00 €
10mg3,648.00 €
Estimated delivery in United States, on Monday 17 Mar 2025
discount label

Vinorelbine tartrate - Bio-X ™

Controlled Product
CAS:125317-39-7

Ref: 3D-BV300138

10mg147.00 €
Estimated delivery in United States, on Tuesday 18 Mar 2025
discount label

Vinorelbine tartrate

Controlled Product
CAS:125317-39-7

Ref: 3D-FV61484

1g1,252.00 €
50mg209.00 €
100mg334.00 €
250mg559.00 €
500mg832.00 €
Estimated delivery in United States, on Tuesday 18 Mar 2025
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