CAS 125317-39-7

Navelbine

Description:

Navelbine, known by its generic name vinorelbine, is a semi-synthetic vinca alkaloid derived from the periwinkle plant, Catharanthus roseus. It is primarily used as a chemotherapeutic agent in the treatment of various cancers, including non-small cell lung cancer and breast cancer. Vinorelbine functions by inhibiting microtubule formation during cell division, thereby disrupting the mitotic spindle and leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. The compound is typically administered intravenously and has a moderate side effect profile, which may include neutropenia, nausea, and fatigue. Its pharmacokinetics involve hepatic metabolism, primarily through the cytochrome P450 system, and it is excreted mainly in the bile. The CAS number 125317-39-7 uniquely identifies vinorelbine in chemical databases, facilitating research and clinical applications. Overall, Navelbine represents an important therapeutic option in oncology, contributing to improved outcomes in patients with specific malignancies.

Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

InChI: InChI=1S/C45H54N4O8.C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;1-2,5-6H,(H,7,8)(H,9,10)/t28-,37-,38+,39+,42+,43+,44-,45-;1-,2-/m01/s1

InChI key: InChIKey=UUHYRRXICWUZHW-RPZOAHRESA-N

SMILES: C(C)[C@@]12[C@]3([C@@]4([C@]([C@](C(OC)=O)(O)[C@@H]1OC(C)=O)(N(C)C=5C4=CC(=C(OC)C5)[C@]6(C(OC)=O)C7=C(C=8C(N7)=CC=CC8)C[N@@]9C[C@](C6)(C=C(CC)C9)[H])[H])CCN3CC=C2)[H].[C@@H]([C@H](C(O)=O)O)(C(O)=O)O

Synonyms:

• (3Ar,3A1R,4R,5S,5Ar,10Br)-Methyl 4-Acetoxy-3A-Ethyl-9-((2S,6S,8S)-4-Ethyl-8-(Methoxycarbonyl)-1,3,6,7,8,9-Hexahydro-2,6-Methanoazecino[4,3-B]Indol-8-Yl)-5-Hydroxy-8-Methoxy-6-Methyl-3A,3A1,4,5,5A,6,11
• 3',4'-Didehydro-4'-Deoxy-C'-Norvincaleukoblastine
• 3',4'-didehydro-4'-deoxy-c'-norvincaleukoblastine R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt
• 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine tartrate
• 5'-Noranhydrovinoblastine Tartrate
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Bitartrate
• Butanedioate(1:2)
• C'-norvincaleukoblastine,3',4'-didehydro-4'-dioxy-,(R-(R*,R*))-2,3-dihydroxy
• C′-Norvincaleukoblastine, 3′,4′-didehydro-4′-deoxy-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt)
• Kw 2307
• Navelbine
• Navelbine ditartrate
• Navelbine tartrate
• Nor-5′-anhydrovinblastine ditartrate
• Nvb
• Pacilitaxel
• Vinorelbin
• Vinorelbine bitartrate
• Vinorelbine bitratrate
• Vinorelbine ditartaric acid
• Vinorelbine ditartrate salt
• Vinorelbine tartarate
• Vinorelbine tartrate
• Vinorelbine tartrate usp standard
• Vinorelbineditartrate salt hydrate
• [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt]
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)

VINORELBINE TARTRATE CRS

CAS: 125317-39-7

VINORELBINE TARTRATE CRS

Formula: C₄₅H₅₄N₄O₈

Color and Shape: Powder

Molecular weight: 778.9323

Ref: 41-Y0000463

VINORELBINE FOR PEAK IDENTIFICATION A CRS

CAS: 125317-39-7

VINORELBINE FOR PEAK IDENTIFICATION A CRS

Color and Shape: Powder

Ref: 41-Y0001938

VINORELBINE FOR PEAK IDENTIFICATION B CRS

CAS: 125317-39-7

VINORELBINE FOR PEAK IDENTIFICATION B CRS

Color and Shape: Powder

Ref: 41-Y0001939

Vinorelbine Tartrate

CAS: 125317-39-7

Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi

Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Color and Shape: Powder

Molecular weight: 778.39416

Ref: 45-1714506

Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2b,3b,4b,5a,12R,19a)-,(2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)

CAS: 125317-39-7

Formula: C₅₃H₆₆N₄O₂₀

Purity: 95%

Color and Shape: Solid

Molecular weight: 1079.1059

Ref: IN-DA00HI66

Vinorelbine Ditartrate Salt

CAS: 125317-39-7

Vinorelbine Ditartrate Salt

Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Purity: 98%

Color and Shape: white to off-white solid

Molecular weight: 1,079.11g/mol

Ref: 54-BIFK0008

Vinorelbine Ditartrate

CAS: 125317-39-7

Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Color and Shape: White To Off-White Solid

Molecular weight: 778.95 2*150.09

Ref: 4Z-V-040001

Vinorelbine ditartrate

CAS: 125317-39-7

Vinorelbine ditartrate

Purity: ≥98%

Molecular weight: 1079.11g/mol

Ref: 54-BUP13274

Vinorelbine Tartrate

Controlled Product

CAS: 125317-39-7

Formula: C₄₅H₅₄N₄O₈C₄H₆O₆

Color and Shape: Neat

Molecular weight: 1079.11

Ref: 86-MM1252.00

Vinorelbine tartrate

CAS: 125317-39-7

Formula: C₄₅H₅₄N₄O₈C₄H₆O₆

Color and Shape: Neat

Molecular weight: 1079.11

Ref: 04-CA17921850

Vinorelbine Tartrate

CAS: 125317-39-7

Formula: C₄₅H₅₄N₄O₈•2C₄H₆O₆

Purity: 95%~99%

Molecular weight: 1079.11

Ref: BP-BP1446

Vinorelbine Ditartrate

CAS: 125317-39-7

Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 1,079.12

Ref: 3B-V0151

Vinorelbine ditartrate

CAS: 125317-39-7

Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆·xH₂O

Purity: (HPLC) ≥ 98.0% (dried basis)

Color and Shape: White to off-white powder

Molecular weight: 1079.11 (anhydrous)

Ref: 7W-GP5205

Vinorelbine ditartrate

CAS: 125317-39-7

Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor activity. Cost-effective and quality-assured.

Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Purity: 98% - 99.86%

Color and Shape: White To Off-White Crystalline Powder

Molecular weight: 1079.11

Ref: TM-T6213

Vinorelbine-d3 Bitartrate

Controlled Product

CAS: 125317-39-7

Stability Light Sensitive, Temperature Sensitive
Applications An antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Mathe, G., et al.: Cancer Letters, 27, 285 (1985), Levegue, D., et al.: Clin. Pharmacokinet., 31, 184 (1996), Curran, M.P., et al.: Drugs Aging., 19, 695 (2002),

Formula: C₅₃H₆₃D₃N₄O₂₀

Color and Shape: Neat

Molecular weight: 1082.12

Ref: TR-V315002

Vinorelbine Bitartrate

Controlled Product

CAS: 125317-39-7

Stability Temperature Sensitive
Applications An antineoplastic.
References Mathe, G., et al.: Cancer Letters, 27, 285 (1985), Levegue, D., et al.: Clin. Pharmacokinet., 31, 184 (1996), Curran, M.P., et al.: Drugs Aging., 19, 695 (2002),

Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

Color and Shape: White

Molecular weight: 1079.11

Ref: TR-V315000

Vinorelbine tartrate - Bio-X ™

Controlled Product

CAS: 125317-39-7

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₅₃H₆₆N₄O₂₀

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,079.11 g/mol

Ref: 3D-BV300138

Vinorelbine tartrate

Controlled Product

CAS: 125317-39-7

Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid

Formula: C₅₃H₆₆N₄O₂₀

Purity: (Hplc) Min. 98.0%

Color and Shape: White Powder

Molecular weight: 1,079.11 g/mol

Ref: 3D-FV61484

Vinorelbine Ditartrate

CAS: 125317-39-7

Formula: C₄₅H₅₄N₄O₈(C₄H₆O₆)

Molecular weight: 778.95 : 2(150.09)

Ref: ST-EA-CP-V49001