CAS 125317-39-7: Navelbine

Description: Navelbine, known by its generic name vinorelbine, is a semi-synthetic vinca alkaloid derived from the periwinkle plant, Catharanthus roseus. It is primarily used as a chemotherapeutic agent in the treatment of various cancers, including non-small cell lung cancer and breast cancer. Vinorelbine functions by inhibiting microtubule formation during cell division, thereby disrupting the mitotic spindle and leading to cell cycle arrest and apoptosis in rapidly dividing cancer cells. The compound is typically administered intravenously and has a moderate side effect profile, which may include neutropenia, nausea, and fatigue. Its pharmacokinetics involve hepatic metabolism, primarily through the cytochrome P450 system, and it is excreted mainly in the bile. The CAS number 125317-39-7 uniquely identifies vinorelbine in chemical databases, facilitating research and clinical applications. Overall, Navelbine represents an important therapeutic option in oncology, contributing to improved outcomes in patients with specific malignancies.

Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆

InChI: InChI=1S/C45H54N4O8.C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;1-2,5-6H,(H,7,8)(H,9,10)/t28-,37-,38+,39+,42+,43+,44-,45-;1-,2-/m01/s1

InChI key: InChIKey=UUHYRRXICWUZHW-RPZOAHRESA-N

SMILES: O=C(O)C(O)C(O)C(=O)O.O=C(OC1C(O)(C(=O)OC)C2N(C3=CC(OC)=C(C=C3C42CCN5CC=CC1(CC)C54)C6(C(=O)OC)C=7NC=8C=CC=CC8C7CN9CC(=CC(C9)C6)CC)C)C

Synonyms:

• (3Ar,3A1R,4R,5S,5Ar,10Br)-Methyl 4-Acetoxy-3A-Ethyl-9-((2S,6S,8S)-4-Ethyl-8-(Methoxycarbonyl)-1,3,6,7,8,9-Hexahydro-2,6-Methanoazecino[4,3-B]Indol-8-Yl)-5-Hydroxy-8-Methoxy-6-Methyl-3A,3A1,4,5,5A,6,11
• 3',4'-Didehydro-4'-Deoxy-C'-Norvincaleukoblastine
• 3',4'-didehydro-4'-deoxy-c'-norvincaleukoblastine R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt
• 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine tartrate
• 5'-Noranhydrovinoblastine Tartrate
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12β,19α)-, (2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)
• Bitartrate
• Butanedioate(1:2)
• C'-norvincaleukoblastine,3',4'-didehydro-4'-dioxy-,(R-(R*,R*))-2,3-dihydroxy
• C′-Norvincaleukoblastine, 3′,4′-didehydro-4′-deoxy-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:2) (salt)
• Kw 2307
• Navelbine
• Navelbine ditartrate
• Navelbine tartrate
• Nor-5′-anhydrovinblastine ditartrate
• Nvb
• Pacilitaxel
• Vinorelbin
• Vinorelbine bitartrate
• Vinorelbine bitratrate
• Vinorelbine ditartaric acid
• Vinorelbine ditartrate salt
• Vinorelbine tartarate
• Vinorelbine tartrate
• Vinorelbine tartrate usp standard
• Vinorelbineditartrate salt hydrate
• [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2) salt]
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
• methyl (2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(acetyloxy)-15-[(8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-6,7-didehydroaspidospermidine-3-carboxylate 2,3-dihydroxybutanedioate (1:2)
• Vinorelbine ditartrate

Vinorelbine for peak identification B CRS

CAS: 125317-39-7

• Color and Shape: Powder

Vinorelbine for peak identification A CRS

CAS: 125317-39-7

• Color and Shape: Powder

Vinorelbine tartrate CRS

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈
• Color and Shape: Powder
• Molecular weight: 778.9323

Vinorelbine Tartrate

CAS: 125317-39-7

Other alkaloids,natural or reproduced by synthesis, and their salts, ethers,esters&other derivatives, nesoi

• Formula: C₄₅H₅₄N₄O₈· 2C₄H₆O₆
• Color and Shape: Powder
• Molecular weight: 778.39416

Aspidospermidine-3-carboxylic acid,4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2b,3b,4b,5a,12R,19a)-,(2R,3R)-2,3-dihydroxybutanedioate (1:2) (salt)

CAS: 125317-39-7

• Formula: C₅₃H₆₇N₄O₂₀
• Color and Shape: Solid
• Molecular weight: 1080.1139

Vinorelbine Ditartrate Salt

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆
• Purity: 98%
• Color and Shape: white to off-white solid
• Molecular weight: 1,079.11g/mol

Vinorelbine Ditartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Color and Shape: White To Off-White Solid
• Molecular weight: 778.95 2*150.09

Vinorelbine Ditartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆
• Purity: >95.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 1,079.12

Vinorelbine Tartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Color and Shape: Neat
• Molecular weight: 1079.11

Vinorelbine Tartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈•2C₄H₆O₆
• Purity: 95%~99%
• Molecular weight: 1079.11

Vinorelbine tartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Color and Shape: Neat
• Molecular weight: 1079.11

Vinorelbine tartrate, 98%

CAS: 125317-39-7

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₅₃H₆₆N₄O₂₀
• Purity: 98%
• Color and Shape: White to almost white, Powder
• Molecular weight: 1079.12

Vinorelbine ditartrate

CAS: 125317-39-7

• Formula: C₄₅H₅₄N₄O₈· 2C₄H₆O₆·xH₂O
• Purity: (HPLC) ≥ 98.0% (dried basis)
• Color and Shape: White to off-white powder
• Molecular weight: 1079.11 (anhydrous)

Vinorelbine ditartrate

CAS: 125317-39-7

Vinorelbine ditartrate (KW-2307) is a natural alkaloid and an anti-mitotic agent. Vinorelbine ditartrate has anti-tumor …

• Formula: C₄₅H₅₄N₄O₈·2C₄H₆O₆
• Purity: 98% - 99.86%
• Color and Shape: White To Off-White Crystalline Powder
• Molecular weight: 1079.11

Vinorelbine Bitartrate

CAS: 125317-39-7

Stability Temperature Sensitive Applications An antineoplastic. References Mathe, G., et al.: Cancer Letters, 27, 285 …

• Formula: C₄₅H₅₄N₄O₈C₄H₆O₆
• Color and Shape: White
• Molecular weight: 1079.11

Vinorelbine-d3 Bitartrate

CAS: 125317-39-7

Stability Light Sensitive, Temperature Sensitive Applications An antineoplastic. Not a dangerous good if item is …

• Formula: C₅₃H₆₃D₃N₄O₂₀
• Color and Shape: Neat
• Molecular weight: 1082.12

Vinorelbine tartrate - Bio-X ™

CAS: 125317-39-7

This product is part of our Bio-X ™ Range. These products are aimed at life …

• Formula: C₅₃H₆₆N₄O₂₀
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 1,079.11 g/mol

Vinorelbine tartrate

CAS: 125317-39-7

Microtubule disrupter; anti-mitotic drug; anti-cancer alkaloid

• Formula: C₅₃H₆₆N₄O₂₀
• Purity: (Hplc) Min. 98.0%
• Color and Shape: White Powder
• Molecular weight: 1,079.11 g/mol