CAS 125354-16-7

N-Debenzoyl-N-(tert-butoxycarbonyl)taxol

Description:

N-Debenzoyl-N-(tert-butoxycarbonyl)taxol, identified by its CAS number 125354-16-7, is a derivative of the well-known chemotherapeutic agent paclitaxel (Taxol). This compound features a modified structure that includes a tert-butoxycarbonyl (Boc) group and a debenzoyl modification, which alters its pharmacological properties. The presence of the Boc group enhances the compound's stability and solubility, making it more amenable for various chemical reactions and potential applications in drug delivery systems. The debenzoylation process can influence the compound's interaction with biological targets, potentially affecting its efficacy and toxicity profile. As a synthetic intermediate, it may be utilized in the development of novel anticancer agents or in research focused on improving the therapeutic index of taxol derivatives. Overall, N-Debenzoyl-N-(tert-butoxycarbonyl)taxol represents a significant modification of the taxol structure, aimed at enhancing its pharmaceutical properties while retaining its core anticancer activity.

Formula: C₄₅H₅₅NO₁₅

InChI: InChI=1/C45H55NO15/c1-23-28(58-39(53)33(50)32(26-16-12-10-13-17-26)46-40(54)61-41(4,5)6)21-45(55)37(59-38(52)27-18-14-11-15-19-27)35-43(9,29(49)20-30-44(35,22-56-30)60-25(3)48)36(51)34(57-24(2)47)31(23)42(45,7)8/h10-19,28-30,32-35,37,49-50,55H,20-22H2,1-9H3,(H,46,54)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1

Synonyms:

• (2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• benzenepropanoic acid, beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (alphaR,betaS)-
• (2alpha,5beta,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 10-Acetyltaxotere
• Docetaxal
• 10-Acetyldocetaxel
• Docetaxel Impurity 7(Docetaxel EP Impurity G)
• Docetaxel impurity G
• Docetaxel EP Impurity G (10-Acetyl Docetaxel)
• Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,...
• CS-878
• DOCETAXOL
• Docetaxel N-Debenzoyl-N-(tert-butoxycarbonyl)taxol
• ACETYLDOCETAXEL, 10-(P)
• Docetaxel impurity 7/Docetaxel EP Impurity G/10-Acetyl Docetaxel/(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dode
• Docetaxel EP Impurity G
• N-Debenzoyl-N-(tert-butoxycarbonyl)taxol
• (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyldiacetate
• PNU 101383

Docetaxal

CAS: 125354-16-7

Docetaxal (10-Acetyl docetaxel) is an analogue of Docetaxel, which is a microtubule inhibitor. Docetaxal can be used in cancer research.

Formula: C₄₅H₅₅NO₁₅

Color and Shape: Solid

Molecular weight: 849.92

Ref: TM-T38644

Docetaxel EP Impurity G (10-Acetyl Docetaxel)

CAS: 125354-16-7

Formula: C₄₅H₅₅NO₁₅

Color and Shape: White To Off-White Solid

Molecular weight: 849.93

Ref: 4Z-D-195

Docetaxal

CAS: 125354-16-7

Docetaxal

Purity: 98%

Molecular weight: 849.92g/mol

Ref: 54-OR1035876

Docetaxal

Controlled Product

CAS: 125354-16-7

Impurity Docetaxel EP Impurity G
Applications Docetaxal (Docetaxel EP Impurity G) is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.
References Zhu, Q.Q., et al.: J. Med. Chem., 40, 4319 (1997); Burkhart, C.A., et al.: Cancer. Res., 54, 5779 (1994); Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)

Formula: C₄₅H₅₅NO₁₅

Color and Shape: Neat

Molecular weight: 849.92

Ref: TR-D494565

Docetaxal-d9

Controlled Product

CAS: 125354-16-7

Formula: C₄₅D₉H₄₆NO₁₅

Color and Shape: Neat

Molecular weight: 858.971

Ref: TR-D494567

Docetaxel EP Impurity G

CAS: 125354-16-7

Formula: C₄₅H₅₅NO₁₅

Molecular weight: 849.87

Ref: ST-EA-CP-D32007

Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-

CAS: 125354-16-7

Formula: C₄₅H₅₅NO₁₅

Color and Shape: Solid

Molecular weight: 849.9159

Ref: IN-DA000NIQ