CAS 125357-12-2

dynorphin A (D-arg8)-fragment 1-13

Description:

Dynorphin A (D-Arg8)-fragment 1-13 is a peptide that is derived from the larger dynorphin A family, which are endogenous opioid peptides. This specific fragment consists of 13 amino acids and is known for its role in modulating pain, stress, and emotional responses through its interaction with opioid receptors, particularly the kappa-opioid receptor. The presence of the D-arginine at position 8 enhances its stability and bioactivity compared to its natural counterpart. This peptide exhibits characteristics typical of opioid peptides, including analgesic properties and potential effects on mood and behavior. It is often studied for its implications in neurobiology and pharmacology, particularly in the context of pain management and addiction. Additionally, due to its specific structure, it may have unique binding affinities and pharmacokinetic profiles, making it a subject of interest in drug development and therapeutic applications. As with many peptides, its stability, solubility, and bioavailability are critical factors influencing its effectiveness in biological systems.

Formula: C₇₅H₁₂₇N₂₇O₁₅

Synonyms:

• (D-Arg8)-Dynorphin A (1-13)
• H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-D-Arg-Arg-Pro-Lys-Leu-Lys-OH