CAS 1254053-43-4

6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide

Description:

6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide, with CAS number 1254053-43-4, is a synthetic organic compound characterized by its complex molecular structure, which includes multiple functional groups such as amines, methoxy, and a pyrazine ring. This compound is notable for its potential pharmacological properties, often explored in the context of medicinal chemistry and drug development. The presence of piperazine and piperidine moieties suggests possible interactions with biological targets, particularly in the central nervous system. Its solubility and stability can vary based on the specific conditions, such as pH and temperature, which are critical for its application in biological assays. Additionally, the compound's molecular weight and specific stereochemistry can influence its biological activity and pharmacokinetics. As with many complex organic molecules, thorough characterization through techniques like NMR, mass spectrometry, and crystallography is essential for understanding its properties and potential uses in therapeutic contexts.

Formula: C₂₉H₄₄N₈O₃

InChI: InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)

InChI key: InChIKey=GYQYAJJFPNQOOW-UHFFFAOYSA-N

SMILES: N(C=1C(C(N)=O)=NC(CC)=C(NC2CCOCC2)N1)C3=CC(OC)=C(C=C3)N4CCC(CC4)N5CCN(C)CC5

Synonyms:

• Gilteritinib
• 2-Pyrazinecarboxamide, 6-ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-
• 6-Ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-2-pyrazinecarboxamide
• ASP 2215

2-Pyrazinecarboxamide, 6-ethyl-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[(tetrahydro-2H-pyran-4-yl)amino]-

CAS: 1254053-43-4

Formula: C₂₉H₄₄N₈O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 552.7115

Ref: IN-DA000NMP

6-Ethyl-3-((3-Methoxy-4-(4-(4-Methylpiperazin-1-Yl)Piperidin-1-Yl)Phenyl)Amino)-5-((Tetrahydro-2H-Pyran-4-Yl)Amino)Pyrazine-2-Carboxamide

CAS: 1254053-43-4

6-Ethyl-3-((3-Methoxy-4-(4-(4-Methylpiperazin-1-Yl)Piperidin-1-Yl)Phenyl)Amino)-5-((Tetrahydro-2H-Pyran-4-Yl)Amino)Pyrazine-2-Carboxamide

Purity: 97%

Molecular weight: 552.71g/mol

Ref: 54-OR1024226

Gilteritinib

CAS: 1254053-43-4

Formula: C₂₉H₄₄N₈O₃

Color and Shape: Yellow Solid

Molecular weight: 552.72

Ref: 4Z-G-197001

Gilteritinib

CAS: 1254053-43-4

Gilteritinib

Purity: ≥95%

Molecular weight: 552.71g/mol

Ref: 54-BUP15308

Gilteritinib

CAS: 1254053-43-4

Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM,

Formula: C₂₉H₄₄N₈O₃

Purity: 97.75% - 99.90%

Color and Shape: Solid

Molecular weight: 552.71

Ref: TM-T4409

Gilteritinib

CAS: 1254053-43-4

Purity: 95%

Molecular weight: 552.723999023438

Ref: 10-F799808

Gilteritinib

CAS: 1254053-43-4

Inhibitor of FLT3 and AXL tyrosine kinases

Formula: C₂₉H₄₄N₈O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 552.71 g/mol

Ref: 3D-BG166434

Gilteritinib d5

Controlled Product

CAS: 1254053-43-4

Formula: C₂₉H₃₉D₅N₈O₃

Color and Shape: Neat

Molecular weight: 557.75

Ref: TR-G377701

Gilteritinib

Controlled Product

CAS: 1254053-43-4

Applications Gilteritinib is an AXL inhibitor in cancer.
References Myers, S., et al.: J. Med. Chem. (2015)

Formula: C₂₉H₄₄N₈O₃

Color and Shape: Neat

Molecular weight: 552.71

Ref: TR-G377700