CAS 125481-61-0

6-HYDROXY BUSPIRONE

Description:

6-Hydroxy buspirone is a chemical compound that belongs to the class of anxiolytics, primarily used for the treatment of anxiety disorders. It is a derivative of buspirone, which is known for its action as a serotonin receptor agonist, particularly at the 5-HT1A receptor. The presence of the hydroxyl group at the 6-position enhances its pharmacological profile. This compound exhibits a moderate affinity for dopamine receptors and may influence neurotransmitter systems, contributing to its anxiolytic effects. In terms of physical properties, 6-hydroxy buspirone is typically a white to off-white solid, and its solubility can vary depending on the solvent used. The compound is often studied for its potential therapeutic benefits and mechanisms of action in the central nervous system. As with many pharmaceuticals, understanding its pharmacokinetics, metabolism, and potential side effects is crucial for its application in clinical settings. Research continues to explore its efficacy and safety profile in various therapeutic contexts.

Formula: C₂₁H₃₁N₅O₃

InChI: InChI=1/C21H31N5O3/c27-17-16-21(6-1-2-7-21)18(28)19(29)26(17)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9,18,28H,1-4,6-7,10-16H2

SMILES: C1CCC2(C1)CC(=O)N(CCCCN1CCN(CC1)c1ncccn1)C(=O)C2O

Synonyms:

• 6-Hydroxy-8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9- dione
• Bmy 28674
• 6-Hydroxy-8-[4-(4-Pyrimidin-2-Ylpiperazin-1-Yl)Butyl]-8-Azaspiro[4.5]Decane-7,9-Dione

10-Hydroxy-8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione

CAS: 125481-61-0

Formula: C₂₁H₃₁N₅O₃

Color and Shape: Solid

Molecular weight: 401.5025

Ref: IN-DA000NPO

6-Hydroxy Buspirone

CAS: 125481-61-0

Formula: C₂₁H₃₁N₅O₃

Color and Shape: White To Off-White Solid

Molecular weight: 401.51

Ref: 4Z-B-071

6'-Hydroxy Buspirone

Controlled Product

CAS: 125481-61-0

Applications It is a major active metabolite of Buspirone (B689850).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rabiner, E., et al.: Nucl. Med. Biol., 27, 509 (2000), Zhu, M., et al.: Drug Metab. Dispos., 33, 500 (2005), Dockens, R., et al.: J. Clin. Pharmacol., 46, 1308 (2006), Wong, H., et al.: Drug Metab. Dispos., 35, 1387 (2007),

Formula: C₂₁H₃₁N₅O₃

Color and Shape: Light Yellow

Molecular weight: 401.5

Ref: TR-H830800

6'-Hydroxy buspirone

CAS: 125481-61-0

6'-Hydroxy buspirone is a prodrug of buspirone, which is an antidepressant drug. It has been shown to have a matrix effect and profile similar to that of buspirone in humans. The compound has been found to be effective in the treatment of depression. 6'-Hydroxy buspirone has been shown to inhibit the dopamine D3 receptor with a potency similar to that of buspirone and other dopamine antagonists. This inhibition may be responsible for the antidepressant effects observed in clinical trials. The compound also inhibits serotonin reuptake, which may account for its antidepressant activity. 6'-Hydroxy buspirone is not metabolized by cytochrome P450 enzymes, making it more selective than some other drugs that are metabolized by this enzyme system.

Formula: C₂₁H₃₁N₅O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 401.5 g/mol

Ref: 3D-FH23929

6-hydroxy Buspirone

CAS: 125481-61-0

6-Hydroxy Buspirone, an active metabolite of the anxiolytic compound buspirone, is produced via the cytochrome P450 (CYP) isoform CYP3A4.

Formula: C₂₁H₃₁N₅O₃

Color and Shape: Solid

Molecular weight: 401.50

Ref: TM-T83909

6-Hydroxy buspirone

CAS: 125481-61-0

Formula: C₂₁H₃₁N₅O₃

Molecular weight: 401.51

Ref: ST-EA-CP-B22022