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CAS 125494-59-9

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Sibutramine hydrochloride monohydrate

Description:
Sibutramine hydrochloride monohydrate is a synthetic compound primarily used as an appetite suppressant in the management of obesity. It functions as a serotonin-norepinephrine reuptake inhibitor, enhancing the levels of these neurotransmitters in the brain, which can lead to reduced hunger and increased satiety. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for various pharmaceutical formulations. Its chemical formula includes a hydrochloride salt and a monohydrate, indicating the presence of one water molecule per formula unit. Sibutramine has been associated with cardiovascular risks, leading to its withdrawal from many markets, including the European Union and the United States. As a controlled substance in several countries, it is important to handle it with caution and under appropriate regulations. Its pharmacokinetics involve extensive metabolism in the liver, and it is primarily excreted through urine. Overall, while it has been effective for weight management, its safety profile necessitates careful consideration in clinical use.
Formula:C17H26ClN·ClH·H2O
InChI:InChI=1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2
InChI key:InChIKey=KFNNPQDSPLWLCX-UHFFFAOYSA-N
SMILES:C(CC(C)C)(N(C)C)C1(CCC1)C2=CC=C(Cl)C=C2.Cl.O
Synonyms:
  • 1-(4-CHLOROPHENYL)-N,N-DIMETHYL-BETA-(2-METHYLPROPYL)CYCLOBUTANEMETHANAMINE HYDROCHLORIDE hydrate
  • 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine hydrochloride hydrate
  • Cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-, hydrochloride, hydrate (1:1:1)
  • Cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-α-(2-methylpropyl)-, hydrochloride, monohydrate
  • Intermediate of Sibutramine hydrochloride hydrate
  • SIBUTRAMINEHYDROCHLORIDE hydrate
  • Sibutramine Hcl Monohydrate
  • Sibutramine Hcl hydrate
  • Sibutramine Hydrochloride Monohydrate
  • Sibutramine・HCL hydrate
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