CAS 1254944-66-5

SR8278

Description:

SR8278, with the CAS number 1254944-66-5, is a chemical compound that has garnered attention in the field of medicinal chemistry, particularly for its potential therapeutic applications. It is classified as a selective inhibitor of certain protein kinases, which play crucial roles in various cellular processes, including cell growth and division. The compound exhibits a specific mechanism of action that targets pathways involved in cancer progression, making it a candidate for cancer treatment research. In terms of its physical and chemical properties, SR8278 is typically characterized by its molecular structure, which includes specific functional groups that contribute to its biological activity. The compound's solubility, stability, and reactivity are also important characteristics that influence its efficacy and safety profile in biological systems. As research continues, further studies are likely to elucidate its pharmacokinetics, pharmacodynamics, and potential side effects, contributing to a better understanding of its role in therapeutic applications.

Formula: C₁₈H₁₉NO₃S₂

Synonyms:

• 3-Isoquinolinecarboxylic acid, 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-, ethyl ester
• SR8278
• UIEBLUZPSFAFOC-UHFFFAOYSA-N
• Ethyl 1,2,3,4-tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylate
• 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester
• SR8278;SR-8278;SR 8278
• ethyl2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate

SR8278

CAS: 1254944-66-5

Formula: C₁₈H₁₉NO₃S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 361.4784

Ref: IN-DA009E6N

SR8278

CAS: 1254944-66-5

SR8278

Purity: ≥98%

Molecular weight: 361.48g/mol

Ref: 54-BUP14385

Sr 8278

CAS: 1254944-66-5

Sr 8278

Purity: 98%

Molecular weight: 361.48g/mol

Ref: 54-OR1022995

SR8278

CAS: 1254944-66-5

SR8278 is an REV-ERBα antagonist(EC50 = 0.47 μM), blocking activation of the receptor by the synthetic agonist GSK 4112

Formula: C₁₈H₁₉NO₃S₂

Purity: 99.44% - 99.73%

Color and Shape: Solid

Molecular weight: 361.48

Ref: TM-T7837

SR 8278

Controlled Product

CAS: 1254944-66-5

Applications SR 8278 is a synthetic antagonist of the nuclear heme receptor REV-ERB.
References Kojetin, D., et al.: ACS. Chem. Biol., 6, 131 (2011);

Formula: C₁₈H₁₉NO₃S₂

Color and Shape: Neat

Molecular weight: 361.48

Ref: TR-S684250

SR 8278-d5

Controlled Product

CAS: 1254944-66-5

Applications SR 8278-d5 is the isotope labelled analog of SR 8278 (S684250); a synthetic antagonist of the nuclear heme receptor REV-ERB.
References Kojetin, D., et al.: ACS. Chem. Biol., 6, 131 (2011)

Formula: C₁₈D₅H₁₄NO₃S₂

Color and Shape: Neat

Molecular weight: 366.509

Ref: TR-S684253

SR 8278-d3

Controlled Product

CAS: 1254944-66-5

Formula: C₁₈D₃H₁₆NO₃S₂

Color and Shape: Neat

Molecular weight: 364.497

Ref: TR-S684252

SR8278

CAS: 1254944-66-5

SR8278 is a synthetic, chemical compound that functions as a highly selective inverse agonist of the Rev-Erb nuclear receptors, which is derived from extensive biochemical research. It operates by binding to these orphan nuclear receptors, Rev-Erbα and Rev-Erbβ, inhibiting their activity. This antagonistic action disrupts the regulation of circadian rhythms, metabolism, and inflammatory responses that these receptors typically control. This modulation occurs at the transcriptional level, where SR8278 interferes with gene expression governed by Rev-Erb receptors.

Formula: C₁₈H₁₉NO₃S₂

Purity: Min. 95%

Molecular weight: 361.48 g/mol

Ref: 3D-EAC94466