CAS 1255386-16-3

Regorafenib D3

Description:

Regorafenib D3 is a deuterated analog of regorafenib, a multi-kinase inhibitor primarily used in the treatment of certain types of cancer, including colorectal cancer and gastrointestinal stromal tumors. The deuteration in Regorafenib D3 involves the substitution of hydrogen atoms with deuterium, which can enhance the stability and pharmacokinetic properties of the compound. This modification may also aid in metabolic studies and drug development by providing insights into the drug's behavior in biological systems. Regorafenib itself works by inhibiting various kinases involved in tumor growth and angiogenesis, thereby disrupting the signaling pathways that promote cancer progression. The chemical structure of Regorafenib D3 retains the core features of regorafenib, including its ability to target multiple receptors, but the presence of deuterium can influence its interaction with enzymes and metabolic pathways. As with any pharmaceutical compound, the specific characteristics, including solubility, stability, and bioavailability, are critical for its efficacy and safety in clinical applications.

Formula: C₂₁H₁₂ClD₃F₄N₄O₃

Synonyms:

• Regorafenib D3 Q: What is the CAS Number of
• Regorafenib D3 Q: What are the applications of
• BAY 73-4506 D3
• [2H3]-Regorafenib
• Regorafenib D3
• Regorafenib D3Q: What is
• Regorafenib D3 Q: What is the storage condition of

Regorafenib-d3

CAS: 1255386-16-3

Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.

Formula: C₂₁H₁₅ClF₄N₄O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 485.83

Ref: TM-T12698

Regorafenib-d3

Controlled Product

CAS: 1255386-16-3

Applications Regorafenib-d3 is the isotope labelled analog of Regorafenib (R143000); a compound that inhibits PDGFR tyrosine kinase with IC50=83nM and is useful for the treatment of inflammation. Also an anti-proliferative agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Leuner, C., et al.: Eur. J. Pharm. Biopharm., 50, 47 (2000)

Formula: C₂₁H₁₂D₃ClF₄N₄O₃

Color and Shape: Neat

Molecular weight: 485.83

Ref: TR-R143002

Regorafenib-d3

CAS: 1255386-16-3

Regorafenib-d3 is a synthetic, high purity, fluorescent analog of regorafenib. It is a potent inhibitor of the receptor tyrosine kinase, RET. This drug has been shown to inhibit RET with an IC50 of 0.1 nM in vitro and inhibits proliferation in cell culture assays. It is also an agonist for the ion channel TRPV4 and can be used as a research tool for investigating protein interactions.

Formula: C₂₁H₁₅ClF₄N₄O₃

Purity: Min. 95%

Molecular weight: 485.8 g/mol

Ref: 3D-FAC38616

2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-(methyl-d3)-

CAS: 1255386-16-3

Formula: C₂₁H₁₂ClD₃F₄N₄O₃

Purity: 99%

Color and Shape: Solid

Molecular weight: 485.8339

Ref: IN-DA000NTP