CAS 1256490-31-9

Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-dibenzoate,(2'R)-

Description:

Cytidine, N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-, 3',5'-dibenzoate, (2'R)-, is a synthetic nucleoside derivative characterized by the presence of a benzoyl group and two benzoate moieties attached to the cytidine structure. This compound features a deoxyribose sugar with specific modifications at the 2' position, including a fluorine atom and a methyl group, which can influence its biological activity and stability. The stereochemistry at the 2' position is designated as (2'R), indicating a specific spatial arrangement that may affect its interaction with biological targets, such as nucleic acid synthesis or enzyme activity. The presence of the benzoyl and benzoate groups can enhance lipophilicity, potentially improving membrane permeability. This compound may be of interest in medicinal chemistry and biochemistry for its potential applications in nucleoside analogs, antiviral research, or as a tool in molecular biology. As with many synthetic derivatives, its properties, such as solubility, stability, and reactivity, would be influenced by the specific functional groups and their arrangement within the molecular structure.

Formula: C₃₁H₂₆FN₃O₇

Synonyms:

• 3',5'-O-4-Tribenzoyl-2'-deoxy-2'-fluoro-2'-C-methylcytidine
• (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• 2'-Deoxy-2'-Fluoro-2'-Methyl-N-(Phenylcarbonyl) Cytidine
• (2'R)-N-Benzoyl-2'-deoxy-2'-fluoro-2'-methylcytidine 3',5'-dibenzoate
• PSI-6130 derivative
• N-benzoyl-3,5-di-O-benzoyl-2-deoxy-2-fluoro-2-methylcytidine
• Sofosbuvir N-3
• ((2R,3R,4R,5R)-5-(benzamido-2-oxopyrimidin-1(2H)-yl)-2-(benzoyloxymethyl)-4-fluoro-4-methyltetrahydrofuran-3-yl
• (2R,3R,4R,5R)-5-4-benzamide-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate
• [(2R,3R,4R,5R)-5-(4-benzamido-2-oxo-1,2-dihydropyrimidin-1-yl)-3-(benzoyloxy)-4-fluoro-4-methyloxolan-2-yl]methyl benzoate
• Cytidine, N-Benzoyl-2'-Deoxy-2'-Fluoro-2'-Methyl-3',5'-Dibenzoate, (2'R)-
• Cytidine,N-benzoyl-2'-deoxy-2'-fluoro-2'-methyl-,3',5'-dibenzoate,(2'R)

L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-methylethyl ester

CAS: 1256490-31-9

Formula: C₁₈H₂₁N₂O₇P

Purity: 98%

Color and Shape: Solid

Molecular weight: 408.3423

Ref: IN-DA000O8T

L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-methylethyl ester

CAS: 1256490-31-9

L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-methylethyl ester

Purity: 98%

Molecular weight: 408.34g/mol

Ref: 54-OR1007688

Remdesivir Impurity 25

CAS: 1256490-31-9

Formula: C₁₈H₂₁N₂O₇P

Molecular weight: 408.35

Ref: 4Z-R-137043

L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-methylethyl ester

CAS: 1256490-31-9

Purity: 98%

Molecular weight: 408.11

Ref: 10-F554459

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester

Controlled Product

CAS: 1256490-31-9

Applications N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)

Formula: C₁₅H₁₄O₂

Color and Shape: Neat

Molecular weight: 226.27

Ref: TR-N497030

Remdesivir Impurity 25

CAS: 1256490-31-9

Formula: C₁₈H₂₁N₂O₇P

Molecular weight: 408.35

Ref: ST-EA-CP-R40039