CAS 1256490-48-8

N-[(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester (Mixture)

Controlled Product

CAS: 1256490-48-8

Applications N-[(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester Mixture is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)

Formula: C₁₈H₂₁N₂O₇P

Color and Shape: Neat

Molecular weight: 408.34

Ref: TR-N497035