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CAS 1256584-81-2

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Found 2 products.
  • Alectinib Impurity 29
    TLC
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    Alectinib Impurity 29

    CAS:
    Formula:C28H29N3O3
    Molecular weight:455.56

    Ref: 4Z-A-239041

    5mg
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    100mg
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  • 8-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazol…
    TRC
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    8-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

    Controlled Product
    CAS:
    <p>Applications 8-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-9-ethyl-6,11-dihydro-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile is an intermediate used in the synthesis of Alectinib M4 metabolite (A521150), which is the major active metabolite of Alectinib. Alectinib is an anaplastic lymphoma kinase (ALK) inhibitor and is used to treat non-​small-​cell lung cancer by blocking the activity of anaplastic lymphoma kinase (ALK).<br>References Heinig, K., et al.: Bioanalysis, 8, 1465-79 (2016); Morcos, P.N., et al.: Xenobiotica, 47, 217-29 (2017);<br></p>
    Formula:C28H29N3O3
    Color and Shape:Neat
    Molecular weight:455.548

    Ref: TR-D485310

    100mg
    1,022.00€