CAS 125700-35-8

N-(9-fluorenylmethoxycarbonyl)-L-valine-15N

Description:

N-(9-fluorenylmethoxycarbonyl)-L-valine-15N, commonly referred to as Fmoc-Val-15N, is a derivative of the amino acid valine, modified for use in peptide synthesis. The "Fmoc" group indicates that it is protected with a 9-fluorenylmethoxycarbonyl moiety, which is a common protective group used in solid-phase peptide synthesis to prevent unwanted reactions at the amino group. The "15N" designation signifies that the nitrogen atom in the valine side chain is isotopically labeled with nitrogen-15, a stable isotope that is often used in NMR spectroscopy and other analytical techniques to trace and study molecular interactions. This compound is typically a white to off-white solid and is soluble in organic solvents such as dimethylformamide and dichloromethane. Its stability under standard laboratory conditions makes it a valuable reagent in synthetic organic chemistry, particularly in the preparation of labeled peptides for research in biochemistry and molecular biology.

Formula: C₂₀H₂₁NO₄

Synonyms:

• Fmoc-[15N]Val-OH

FMOC-VAL-OH-15N

CAS: 125700-35-8

Formula: C₂₀H₂₁NO₄

Purity: 95.0%

Molecular weight: 340.384

Ref: 10-F512891

Fmoc-[15N]Val-OH

CAS: 125700-35-8

Fmoc-[15N]Val-OH is an epidermal growth factor receptor (EGFR) ligand that can be used to identify phosphorylation sites on EGFR. Fmoc-[15N]Val-OH binds to the tyrosine kinase domain of the EGFR and is phosphorylated by the intracellular protein tyrosine kinases, which leads to receptor activation. This compound has been shown to have a high affinity for human epidermoid carcinoma cells and can be used in cancer research as a potent and selective ligand. Fmoc-[15N]Val-OH is also known as a growth factor and has been shown to stimulate a number of cellular responses such as cell proliferation, migration, differentiation, and adhesion.

Purity: Min. 95%

Ref: 3D-FF111322