CAS 125700-67-6

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

Description:

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate, with CAS number 125700-67-6, is a chemical compound commonly used as a coupling reagent in peptide synthesis and other organic reactions. It features a benzotriazole moiety, which enhances its reactivity and stability, making it effective in facilitating the formation of amide bonds. The presence of the tetramethyluronium group contributes to its ability to activate carboxylic acids, promoting their conversion into more reactive species. This compound is typically a white to off-white solid and is soluble in polar organic solvents. Its tetrafluoroborate counterion provides additional stability and solubility characteristics. As with many coupling reagents, it is important to handle this substance with care, as it may pose health risks if inhaled or ingested. Proper laboratory safety protocols should be followed when working with this compound, including the use of personal protective equipment and appropriate waste disposal methods.

Formula: C₁₁H₁₆N₅O·BF₄

InChI: InChI=1S/C11H16N5O.BF4/c1-13(2)11(14(3)4)15-9-7-5-6-8-10(9)16(17)12-15;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1

InChI key: InChIKey=ZXZJCMUCQIOBGO-UHFFFAOYSA-N

SMILES: C(N(C)C)(N(C)C)=[N+]1C=2C(N(=O)=N1)=CC=CC2.[B+3]([F-])([F-])([F-])[F-]

Synonyms:

• (Benzotriazol-1-yloxy-dimethylamino-methylene)dimethylammonium tetrafluoroborate
• 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-)
• 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-) (1:1)
• 2-(1H-Benzotriazol-1-YL)-1,1,3,3-tetramethyluronium Tetrafluoroborate
• 2-(1H-Benzotriazol-1-yl)-N,N,N′,N′-tetramethylammonium tetrafluoroborate
• Benzotriazol-1-yl-tetramethyluroniumtetrafluoroborate
• Knorr Reagent
• N,N,N',N'-tetramethyl-O-(Benzotriazol-1-YL)uronium Tetrafluoroborate
• N-[(1H-benzotriazol-1-yloxy)(dimethylamino)methylidene]-N-methylmethanaminium Tetrafluoroborate
• O-(1H-Benzotriazol-1-YL)-1,1,3,3-tetramethyl-uronium Tetrafluoroborate
• O-(1H-Benzotriazol-1-YL)-N,N,N',N'-tetramethyluronium Tetrafluoroborate
• O-(1H-Benzotriazole-1-YL) N,N,N',N'-tetramethyl uronium Tetrafluoroborate
• O-(Benzotriazol-1-yl)-N,N,N',N'-tetra methyluronium Tetrafluoroborate
• O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate
• O-(Benzotriazol-l-yl)-N,N,N,N,-tetramethyluronium Tetrafluoroborate
• O-Benzotriazol-1-yl-tetramethyluronium tetrafluoroborate
• O-Benzotriazolyl tetramethylisouronium tetrafluoroborate

TBTU [Coupling Reagent for Peptide]

CAS: 125700-67-6

Formula: C₁₁H₁₆BF₄N₅O

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 321.09

Ref: 3B-B1658

O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, 99%

CAS: 125700-67-6

O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate is used as used for solid-phase peptide synthesis. It is also used to study ten different phosphonium and uronium salt-based coupling reagents, which are used to synthesize four peptides. This Thermo Scientific Chemicals brand p

Formula: C₁₁H₁₆BF₄N₅O

Purity: 99%

Color and Shape: Crystalline powder or powder, White to cream

Molecular weight: 321.09

Ref: 02-L13470

TBTU

CAS: 125700-67-6

TBTU is successfully used as coupling reagent in solid phase peptide synthesis. It acts as an excellent activating reagent causing low racemization during condensation of peptide segments. A study of the structure of TBTU in solid state as well as in solution by Abdelmoty et al. showed that the compound is a guanidinium N-oxide and not an uronium salt.

Formula: C₁₁H₁₆BF₄N₅O

Color and Shape: White

Molecular weight: 321.09

Ref: 01-4013268

1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, tetrafluoroborate(1-) (1:1)

CAS: 125700-67-6

Formula: C₁₁H₁₆BF₄N₅O

Purity: 98%

Color and Shape: Solid

Molecular weight: 321.0823

Ref: IN-DA000OI0

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

CAS: 125700-67-6

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate

Formula: C₁₁H₁₆N₅O·BF₄

Purity: ≥95%

Color and Shape: white crystalline powder

Molecular weight: 321.08224g/mol

Ref: 54-PC0921

TBTU

CAS: 125700-67-6

Formula: C₁₁H₁₆BF₄N₅O

Purity: ≥ 99.0%

Color and Shape: White to almost white powder

Molecular weight: 321.08

Ref: 7W-GE5057

O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium tetrafluoroborate

CAS: 125700-67-6

Formula: C₁₁H₁₆BF₄N₅O

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 321.09

Ref: 10-F009020

TBTU

CAS: 125700-67-6

TBTU is an aminium coupling reagent used for amide and ester synthesis. TBTU is a stable, efficient and reactive reagent suitable for solution and solid-phase peptide synthesis. With TBTU high yields, racemisation suppression and fast reaction times are achieved. TBTU contains the carbodiimide and benzotriazole moieties, generates HOBt and water-soluble by-products. TBTU can be used in its polymer-bound form as a solid-supported peptide coupling reagent efficient even in presence of water and can be easily separated and regenerated after the reaction. TBTU finds application in the synthesis of biologically active peptides, such as azapeptides.

Formula: C₁₁H₁₆N₅O·BF₄

Purity: Min. 99 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 321.08 g/mol

Ref: 3D-FT07096

TBTU Reagent

CAS: 125700-67-6

TBTU Reagent is a combination of two reagents that are used for peptide synthesis and purification. TBTU is an amide coupling reagent that reacts with the carboxyl group of an ester to form a reactive intermediate, which then reacts with the amino group of an amide. This reaction forms an amide bond between the carboxyl group of the ester and the amino group of the amide. TBTU Reagent has been used in vitro assays to measure pharmacological activities such as anti-inflammatory effects and antimicrobial effects. TBTU Reagent has also been used to prepare mouse monoclonal antibodies against toll-like receptor 4 (TLR4).

Formula: C₁₁H₁₆N₅OBF₄

Purity: Min. 95%

Molecular weight: 321.08 g/mol

Ref: 3D-KTB-1066-PI

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate

CAS: 125700-67-6

Please enquire for more information about O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₁H₁₆BF₄N₅O

Molecular weight: 321.08 g/mol

Ref: 3D-J-523817

TBTU extrapure, 98%

CAS: 125700-67-6

Formula: C₁₁H₁₆BF₄N₅O

Purity: min. 98%

Color and Shape: White, Crystalline powder

Molecular weight: 321.08

Ref: SR-47064

O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate

Controlled Product

CAS: 125700-67-6

Applications O-(Benzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium Tetrafluoroborate is used in the synthesis of tetrapeptoid analogues of the antiprotocoal compound Apicidin (A726300). Also used in the synthesis of acid based t-antigen glycodendrimers.
References Murray, P. et al.: Bioorg. Med. Chem. Lett., 11, 773 (2001); Roy, R. et al.: J. Am. Chem. Soc., 123, 1809 (2001);

Formula: C₁₁H₁₆BF₄N₅O

Color and Shape: Neat

Molecular weight: 321.08

Ref: TR-B206995