CAS 1257044-40-8: ABT-199

Description: ABT-199, also known as Venetoclax, is a small molecule inhibitor primarily designed to target the B-cell lymphoma 2 (BCL-2) protein, which plays a crucial role in regulating apoptosis (programmed cell death). This compound is characterized by its ability to selectively bind to BCL-2, thereby promoting the apoptosis of cancer cells that overexpress this protein, particularly in certain types of hematological malignancies such as chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). ABT-199 exhibits a high degree of specificity for BCL-2 over other BCL-2 family proteins, which contributes to its therapeutic efficacy and safety profile. The substance is administered orally and has been associated with various side effects, including neutropenia and tumor lysis syndrome, necessitating careful monitoring during treatment. Its development marked a significant advancement in targeted cancer therapies, providing a novel approach to treating malignancies that are resistant to conventional therapies. Overall, ABT-199 represents a critical advancement in the field of oncology, particularly for patients with specific BCL-2-dependent cancers.

Formula: C₄₅H₅₀ClN₇O₇S

InChI: InChI=1S/C45H50ClN7O7S/c1-45(2)15-11-33(39(26-45)31-3-5-34(46)6-4-31)29-51-17-19-52(20-18-51)35-7-9-38(42(24-35)60-36-23-32-12-16-47-43(32)49-28-36)44(54)50-61(57,58)37-8-10-40(41(25-37)53(55)56)48-27-30-13-21-59-22-14-30/h3-10,12,16,23-25,28,30,48H,11,13-15,17-22,26-27,29H2,1-2H3,(H,47,49)(H,50,54)

InChI key: InChIKey=LQBVNQSMGBZMKD-UHFFFAOYSA-N

SMILES: O=C(NS(=O)(=O)C1=CC=C(NCC2CCOCC2)C(=C1)N(=O)=O)C3=CC=C(C=C3OC=4C=NC=5NC=CC5C4)N6CCN(CC7=C(C=8C=CC(Cl)=CC8)CC(C)(C)CC7)CC6

Synonyms:

• 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
• Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-
• Gdc-0199
• Rg 7601
• Rg7601
• Venclexta
• Venclyxto
• Venetoclax

Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-

CAS: 1257044-40-8

• Formula: C₄₅H₅₀ClN₇O₇S
• Purity: 99%
• Color and Shape: Solid
• Molecular weight: 868.4392

Venetoclax

CAS: 1257044-40-8

• Formula: C₄₅H₅₀ClN₇O₇S
• Color and Shape: Yellow Solid
• Molecular weight: 868.45

Venetoclax-d8 (piperazine-d8)

CAS: 1257044-40-81257051-06-1

• Purity: 98 atom % D
• Molecular weight: 875.36

Venetoclax

CAS: 1257044-40-8

Venetoclax (ABT-199) is a selective inhibitor of Bcl-2 (Ki < 0.010 nM), binding over 3 orders …

• Formula: C₄₅H₅₀ClN₇O₇S
• Purity: 98% - 99.96%
• Color and Shape: Solid
• Molecular weight: 868.44

ABT 199 (>99%)(Venetoclax)

CAS: 1257044-40-8

Applications ABT 199 (>99%) is a potent and selective BCL-2 inhibitor that achieves potent …

• Formula: C₄₅H₅₀ClN₇O₇S
• Color and Shape: Light Yellow To Yellow
• Molecular weight: 868.44

ABT 199 (Venetoclax)

CAS: 1257044-40-8

Applications ABT 199 is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity …

• Formula: C₄₅H₅₀ClN₇O₇S
• Color and Shape: Light Yellow To Yellow
• Molecular weight: 868.44

Venetoclax

CAS: 1257044-40-8

A BCL-2 selective inhibitor with no effect on Bcl-xl and thereby prevents thrombocytopenia. Increased sensitivity …

• Formula: C₄₅H₅₀ClN₇O₇S
• Purity: Min. 98 Area-%
• Color and Shape: Yellow Powder
• Molecular weight: 868.44 g/mol

ABT-199-D10

CAS: 1257044-40-8

Applications ABT-199-D10 is a deuterized form of ABT 199 (A112430), which is a potent and …

• Formula: C₄₅D₁₀H₄₀ClN₇O₇S
• Color and Shape: Neat
• Molecular weight: 878.5