CAS 125791-92-6

H-Ala-Pro-AFC

Description:

H-Ala-Pro-AFC, with the CAS number 125791-92-6, is a synthetic peptide that consists of the amino acids alanine (Ala) and proline (Pro), linked together in a specific sequence. This compound is often utilized in biochemical research, particularly in studies involving enzyme activity and peptide synthesis. The "AFC" in its name typically refers to a fluorescent moiety, which allows for the detection and quantification of the peptide in various assays. H-Ala-Pro-AFC is characterized by its ability to serve as a substrate for certain proteolytic enzymes, making it valuable in the study of protease activity. Its structure contributes to its stability and solubility in aqueous solutions, which is essential for experimental applications. Additionally, the presence of the fluorescent tag enhances its utility in fluorescence-based assays, enabling researchers to monitor reactions in real-time. Overall, H-Ala-Pro-AFC is a versatile tool in molecular biology and biochemistry, aiding in the understanding of protein interactions and enzymatic processes.

Formula: C₁₈H₁₈F₃N₃O₄

Synonyms:

• Ala-Pro-7-Amino-4-Trifluoro-Methylcoumarin
• Ala-Pro-Afc
• Ap-Afc

H-Ala-Pro-AFC

CAS: 125791-92-6

Fluorogenic substrate for dipeptidyl peptidase IV (DPP IV) and Xaa-Pro dipeptidase. Substrate for fibroblast activation protein alpha (FAP, also called antiplasmin-cleaving enzyme, APCE).

Formula: C₁₈H₁₈F₃N₃O₄

Purity: > 97%

Color and Shape: White Powder

Molecular weight: 397.35

Ref: 01-4026747

H-Ala-Pro-AFC TFA

CAS: 125791-92-6

H-Ala-Pro-AFC TFA is a peptide that is composed of an amino acid sequence derived from the collagen sequence. This peptide has been shown to inhibit the activity of dpp-4, which regulates insulin and glucagon secretion. H-Ala-Pro-AFC TFA also inhibits protease activity in the colon, which may be due to its ability to stabilize collagen in the tissue. It also has anti-cancer properties, inhibiting tumor growth and cell lysis. In addition, it inhibits dextran sulfate induced colitis and experimental colitis in mice by reducing inflammation.

Formula: C₁₈H₁₈F₃N₃O₄·C₂HF₃O₂

Purity: Min. 95%

Molecular weight: 511.37 g/mol

Ref: 3D-FA110570