CAS 1258226-87-7

Ombitasvir

Description:

Ombitasvir is a pharmaceutical compound primarily used in the treatment of hepatitis C virus (HCV) infections. It belongs to the class of direct-acting antiviral agents, specifically as an NS5A inhibitor, which interferes with the viral replication process. Ombitasvir is typically administered in combination with other antiviral medications to enhance its efficacy and reduce the risk of resistance. The compound is characterized by its specific molecular structure, which includes a series of functional groups that contribute to its biological activity. It is generally well-absorbed when taken orally and has a favorable pharmacokinetic profile, allowing for once-daily dosing. Ombitasvir is often part of combination therapies, such as those including paritaprevir and ritonavir, to provide a comprehensive approach to HCV treatment. Its development has significantly improved treatment outcomes for patients with chronic hepatitis C, particularly in specific genotypes of the virus. As with any medication, monitoring for potential side effects and drug interactions is essential during treatment.

Formula: C₅₀H₆₇N₇O₈

InChI: InChI=1S/C50H67N7O8/c1-30(2)42(53-48(62)64-8)46(60)55-28-10-12-40(55)44(58)51-35-20-14-32(15-21-35)38-26-27-39(57(38)37-24-18-34(19-25-37)50(5,6)7)33-16-22-36(23-17-33)52-45(59)41-13-11-29-56(41)47(61)43(31(3)4)54-49(63)65-9/h14-25,30-31,38-43H,10-13,26-29H2,1-9H3,(H,51,58)(H,52,59)(H,53,62)(H,54,63)/t38-,39-,40-,41-,42-,43-/m0/s1

InChI key: InChIKey=PIDFDZJZLOTZTM-KHVQSSSXSA-N

SMILES: C(C)(C)(C)C1=CC=C(N2[C@@H](CC[C@H]2C3=CC=C(NC(=O)[C@H]4N(C([C@@H](NC(OC)=O)C(C)C)=O)CCC4)C=C3)C5=CC=C(NC(=O)[C@H]6N(C([C@@H](NC(OC)=O)[C@@H](C)C)=O)CCC6)C=C5)C=C1

Synonyms:

• 2,2′-[[(2S,5S)-1-[4-(1,1-Dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-<span class="text-smallcaps">L</smallcap>-valyl-<smallcap>L</span>-prolinamide]
• <span class="text-smallcaps">L</smallcap>-Prolinamide, 2,2′-[[(2S,5S)-1-[4-(1,1-dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-<smallcap>L</span>-valyl-
• Ombitasvir
• L-Prolinamide, 2,2′-[[(2S,5S)-1-[4-(1,1-dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-L-valyl-
• ABT 267
• 2,2′-[[(2S,5S)-1-[4-(1,1-Dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-L-valyl-L-prolinamide]

L-Prolinamide, 2,2'-[[(2S,5S)-1-[4-(1,1-dimethylethyl)phenyl]-2,5-pyrrolidinediyl]di-4,1-phenylene]bis[N-(methoxycarbonyl)-L-valyl-

CAS: 1258226-87-7

Formula: C₅₀H₆₇N₇O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 894.1091

Ref: IN-DA000OS1

Ombitasvir

CAS: 1258226-87-7

Ombitasvir

Purity: ≥95%

Molecular weight: 894.11g/mol

Ref: 54-BUP12922

Methyl ((S)-1-((S)-2-((4-((2S,5S)-1-(4-(Tert-Butyl)Phenyl)-5-(4-((S)-1-((Methoxycarbonyl)-L-Valyl)Pyrrolidine-2-Carboxamido)Phenyl)Pyrrolidin-2-Yl)Phenyl)Carbamoyl)Pyrrolidin-1-Yl)-3-Methyl-1-Oxobutan

CAS: 1258226-87-7

Methyl ((S)-1-((S)-2-((4-((2S,5S)-1-(4-(Tert-Butyl)Phenyl)-5-(4-((S)-1-((Methoxycarbonyl)-L-Valyl)Pyrrolidine-2-Carboxamido)Phenyl)Pyrrolidin-2-Yl)Phenyl)Carbamoyl)Pyrrolidin-1-Yl)-3-Methyl-1-Oxobutan

Purity: 98%

Molecular weight: 894.11g/mol

Ref: 54-OR1026363

Ombitasvir

CAS: 1258226-87-7

Formula: C₅₀H₆₇N₇O₈

Molecular weight: 894.13

Ref: 4Z-O-055001

Ombitasvir

CAS: 1258226-87-7

Ombitasvir (ABT-267) inhibits HCV protein NS5A, effective orally, EC50: 0.82-19.3 pM (genotypes 1-5), 366 pM (genotype 6a).

Formula: C₅₀H₆₇N₇O₈

Purity: 97.27% - 99.56%

Color and Shape: Solid

Molecular weight: 894.11

Ref: TM-T7158

Ombitasvir-d6

CAS: 1258226-87-7

Formula: C₅₀H₆₁N₇O₈D₆

Molecular weight: 900.17

Ref: 4Z-O-055003

Ombitasvir-d16

CAS: 1258226-87-7

Formula: C₅₀H₅₁N₇O₈D₁₆

Molecular weight: 910.23

Ref: 4Z-O-055004

Ombitasvir

Controlled Product

CAS: 1258226-87-7

Applications Ombitasvir is a pharmaceutical drug that is used in the treatment of hepatitis C virus in patients with HCV genotype 1 infection. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.
References Feld, J.J., et al.: New Eng. J. Med., 370, 1594 (2014); Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)

Formula: C₅₀H₆₇N₇O₈

Color and Shape: Neat

Molecular weight: 894.11

Ref: TR-O633200

Ombitasvir

CAS: 1258226-87-7

Ombitasvir is a NS5A inhibitor antiviral agent with action on hepatitis C virus replication and is used for treating chronic hepatitis C in combination therapies.

Formula: C₅₀H₆₇N₇O₈

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 894.1 g/mol

Ref: 3D-AO178040

Ombitasvir-d16

Controlled Product

CAS: 1258226-87-7

Formula: C₅₀D₁₆H₅₁N₇O₈

Color and Shape: Neat

Molecular weight: 910.208

Ref: TR-O633202