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CAS 12583-68-5

:

parathyroid hormone bovine fragment*1-34

Description:
Parathyroid hormone bovine fragment 1-34, with the CAS number 12583-68-5, is a peptide that represents the first 34 amino acids of the parathyroid hormone (PTH) derived from bovine sources. This fragment is biologically active and plays a crucial role in calcium homeostasis and bone metabolism. It primarily functions by stimulating osteoclast activity, which leads to increased bone resorption and elevated serum calcium levels. The peptide is characterized by its ability to bind to specific PTH receptors, initiating a cascade of intracellular signaling pathways that influence renal tubular reabsorption of calcium and phosphate. In terms of structure, it consists of a sequence of amino acids that includes key residues essential for receptor interaction and biological activity. This fragment is often used in research and therapeutic applications, particularly in studies related to osteoporosis and metabolic bone diseases. Its stability, solubility, and biological activity make it a valuable tool in both clinical and laboratory settings.
Formula:C183H288N54O50S2
InChI:InChI=1/C174H278N54O49S2/c1-19-93(16)142(228-156(260)110(46-51-137(243)244)208-167(271)126(82-230)224-168(272)139(90(10)11)225-131(235)73-178)171(275)210-106(42-47-127(179)231)143(247)193-78-133(237)200-111(52-59-278-17)153(257)218-119(68-97-76-188-84-197-97)161(265)219-121(70-129(181)233)163(267)213-114(62-87(4)5)145(249)194-79-132(236)199-101(37-25-28-54-175)146(250)217-118(67-96-75-187-83-196-96)160(264)212-113(61-86(2)3)144(248)195-80-134(238)201-125(81-229)166(270)209-112(53-60-279-18)154(258)206-108(44-49-135(239)240)150(254)204-105(41-32-58-191-174(185)186)155(259)226-140(91(12)13)169(273)211-109(45-50-136(241)242)152(256)216-117(66-95-74-192-100-36-24-23-35-99(95)100)159(263)215-116(64-89(8)9)157(261)205-104(40-31-57-190-173(183)184)148(252)202-102(38-26-29-55-176)147(251)203-103(39-27-30-56-177)149(253)214-115(63-88(6)7)158(262)207-107(43-48-128(180)232)151(255)221-123(72-138(245)246)165(269)227-141(92(14)15)170(274)222-120(69-98-77-189-85-198-98)162(266)220-122(71-130(182)234)164(268)223-124(172(276)277)65-94-33-21-20-22-34-94/h20-24,33-36,74-77,83-93,101-126,139-142,192,229-230H,19,25-32,37-73,78-82,175-178H2,1-18H3,(H2,179,231)(H2,180,232)(H2,181,233)(H2,182,234)(H,187,196)(H,188,197)(H,189,198)(H,193,247)(H,194,249)(H,195,248)(H,199,236)(H,200,237)(H,201,238)(H,202,252)(H,203,251)(H,204,254)(H,205,261)(H,206,258)(H,207,262)(H,208,271)(H,209,270)(H,210,275)(H,211,273)(H,212,264)(H,213,267)(H,214,253)(H,215,263)(H,216,256)(H,217,250)(H,218,257)(H,219,265)(H,220,266)(H,221,255)(H,222,274)(H,223,268)(H,224,272)(H,225,235)(H,226,259)(H,227,269)(H,228,260)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,276,277)(H4,183,184,190)(H4,185,186,191)/t93-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,139-,140-,141-,142-/m0/s1
SMILES:CC[C@H](C)[C@@H](C(=N[C@@H](CCC(=N)O)C(=NCC(=N[C@@H](CCSC)C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](CC(=N)O)C(=N[C@@H](CC(C)C)C(=NCC(=N[C@@H](CCCCN)C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](CC(C)C)C(=NCC(=N[C@@H](CO)C(=N[C@@H](CCSC)C(=N[C@@H](CCC(=O)O)C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](C(C)C)C(=N[C@@H](CCC(=O)O)C(=N[C@@H](Cc1c[nH]c2ccccc12)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](CCCCN)C(=N[C@@H](CCCCN)C(=N[C@@H](CC(C)C)C(=N[C@@H](CCC(=N)O)C(=N[C@@H](CC(=O)O)C(=N[C@@H](C(C)C)C(=N[C@@H](Cc1cnc[nH]1)C(=N[C@@H](CC(=N)O)C(=N[C@@H](Cc1ccccc1)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CCC(=O)O)N=C([C@H](CO)N=C([C@H](C(C)C)N=C(CN)O)O)O)O
Synonyms:
  • Parathyroid Hormone 1-34, Bovine
  • Parathyroid Hormone Fragment*Bovine 1-34
  • pTH (1-34) (bovine)
  • H-Ala-Val-Ser-Glu-Ile-Gln-Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH
  • PARATHYROID HORMONE BOVINE: FRAGMENT 1-34
  • bovineparathyroidhormone(1-34
  • AVSEIQFMHNLGKHLSSMERVEWLRKKLQDVHNF
  • parathyroid hormone fragment 1-34 bovine
  • ALA-VAL-SER-GLU-ILE-GLN-PHE-MET-HIS-ASN-LEU-GLY-LYS-HIS-LEU-SER-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE
  • TERIPARATIDE
  • See more synonyms
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50
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