CAS 125830-36-6

NPF-etoposide

Description:

NPF-etoposide, with the CAS number 125830-36-6, is a derivative of the chemotherapeutic agent etoposide, which is primarily used in cancer treatment. This compound is characterized by its mechanism of action, which involves the inhibition of topoisomerase II, an enzyme crucial for DNA replication and repair. By interfering with this enzyme, NPF-etoposide induces DNA strand breaks, leading to apoptosis in rapidly dividing cancer cells. The substance is typically formulated for enhanced solubility and bioavailability compared to its parent compound, potentially improving its therapeutic efficacy. NPF-etoposide may exhibit a modified pharmacokinetic profile, influencing its absorption, distribution, metabolism, and excretion. Additionally, like many chemotherapeutic agents, it may have associated side effects, including myelosuppression, gastrointestinal disturbances, and potential for secondary malignancies. Research into NPF-etoposide continues to explore its effectiveness across various cancer types, as well as its safety profile in clinical settings.

Formula: C₂₇H₂₄FNO₇

InChI: InChI=1/C27H24FNO7/c1-32-21-7-13(8-22(33-2)26(21)30)23-16-9-19-20(36-12-35-19)10-17(16)25(18-11-34-27(31)24(18)23)29-15-5-3-14(28)4-6-15/h3-10,18,23-25,29-30H,11-12H2,1-2H3/t18-,23+,24-,25+/m0/s1

Synonyms:

• (5R-(5alpha,5abeta,8aalpha,9beta))-9-((4-Fluorophenyl)amino)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one
• 4'-O-Demethyl-4-(4''-fluoroanilino)-4-desoxypodophyllotoxin
• 9-((4-Fluorophenyl)amino)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, (5R-(5alpha,5abeta,8aalpha,9beta))-
• Nsc 628679
• Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(5aH)-one, 9-((4-fluorophenyl)amino)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R-(5alpha,5abeta,8abeta,9beta))-
• (5R,5aR,8aS,9S)-9-[(4-fluorophenyl)amino]-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one