CAS 125973-91-3

7-(2'-fluoroethyl)guanine

Description:

7-(2'-fluoroethyl)guanine is a modified nucleobase that belongs to the class of guanine derivatives. This compound features a guanine base with a 2'-fluoroethyl group attached to the nitrogen at the 7-position, which can influence its biological activity and interactions. The presence of the fluorine atom enhances the compound's stability and can affect its hydrogen bonding properties, potentially altering its role in nucleic acid structures. This modification may also impact its incorporation into DNA or RNA, making it of interest in medicinal chemistry and drug design, particularly in the context of antiviral or anticancer therapies. The compound's unique structure may lead to specific interactions with enzymes or receptors, influencing its pharmacological profile. Additionally, the presence of the fluorine atom can enhance lipophilicity, affecting the compound's bioavailability and distribution in biological systems. Overall, 7-(2'-fluoroethyl)guanine represents a significant area of study for researchers exploring nucleobase analogs and their therapeutic applications.

Formula: C₇H₈FN₅O

InChI: InChI=1/C7H8FN5O/c8-1-2-13-3-10-5-4(13)6(14)12-7(9)11-5/h3H,1-2H2,(H3,9,11,12,14)

SMILES: C(Cn1cnc2c1c(nc(=N)[nH]2)O)F

Synonyms:

• 6H-Purin-6-one, 2-amino-7-(2-fluoroethyl)-1,7-dihydro-
• 2-amino-7-(2-fluoroethyl)-3,7-dihydro-6H-purin-6-one
• 7-(2'-Fluoroethyl)guanine