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Atorvastatin lactone

CAS 125995-03-1: Atorvastatin lactone

Description:Atorvastatin lactone, with the CAS number 125995-03-1, is a chemical compound that serves as a precursor to atorvastatin, a widely used statin medication for lowering cholesterol levels. This lactone form is characterized by its cyclic ester structure, which is formed from the reaction of a carboxylic acid and an alcohol. Atorvastatin lactone exhibits lipophilic properties, allowing it to penetrate cell membranes effectively. It is typically a white to off-white solid and is soluble in organic solvents, but has limited solubility in water. The compound is known for its pharmacological activity, as it can inhibit HMG-CoA reductase, an enzyme crucial in the cholesterol biosynthesis pathway. This inhibition leads to a decrease in cholesterol production in the liver, ultimately lowering serum cholesterol levels. Additionally, atorvastatin lactone may undergo hydrolysis in biological systems to yield atorvastatin, which is the active form responsible for its therapeutic effects. As with many pharmaceuticals, the stability and reactivity of atorvastatin lactone are influenced by environmental factors such as pH and temperature.

Formula:C33H33FN2O4

InChI:InChI=1S/C33H33FN2O4/c1-21(2)31-30(33(39)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-27-19-26(37)20-28(38)40-27/h3-16,21,26-27,37H,17-20H2,1-2H3,(H,35,39)/t26-,27-/m1/s1

InChI key:InChIKey=OUCSEDFVYPBLLF-KAYWLYCHSA-N

SMILES:O=C1OC(CCN2C(C=3C=CC(F)=CC3)=C(C=4C=CC=CC4)C(C(=O)NC=5C=CC=CC5)=C2C(C)C)CC(O)C1

  • Synonyms:
  • (4R,6R)-6-{2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-4-hydroxytetrahydro-2H-pyran-2-one
  • 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-, (2R-trans)-
  • 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-
  • 5-(4-Fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydropyran-2-yl]ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
  • 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
  • 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-(1-methylethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
  • 5-(4-fluorophenyl)-2-(1-methyl-ethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
  • Atorvastatin d-Lactone
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Found 11 products.

BrandProduct dataPurityPrice rangeEstimated delivery
British Pharmacopoeia logo
Atorvastatin impurity
REF: 47-1268
CAS:
- - -211.00 €Wed 05 Mar 25
USP logo
Atorvastatin Related Compound H (Lactone Impurity, 5-(4-Fluorophenyl)-1-{2-[(2R, 4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide)
REF: 45-1044582
CAS: 125995-03-1
- - -1,371.00 €Thu 06 Mar 25
Targetmol logo
Atorvastatin lactone
REF: TM-T14342
CAS: 125995-03-1
98.16%38.00 €~283.00 €Fri 07 Mar 25
Indagoo logo
1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-
REF: IN-DA000QNL
CAS: 125995-03-1
95%To inquireFri 07 Mar 25
TLC logo
Atorvastatin EP Impurity H (Atorvastatin USP Related Compound H, Atorvastatin Lactone)
REF: 4Z-A-127
CAS: 125995-03-1
- - -309.00 €~1,288.00 €Mon 10 Mar 25
TLC logo
Atorvastatin EP Impurity H-d5 (Atorvastatin USP Related Compound H-d5, Atorvastatin Lactone-d5)
REF: 4Z-A-1214
CAS: 125995-03-1
- - -To inquireMon 10 Mar 25
TCI logo
Atorvastatin Lactone
REF: 3B-A3114
CAS: 125995-03-1
>95.0%(HPLC)105.00 €~306.00 €Mon 10 Mar 25
Mikromol logo
(4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl]-4-hydroxytetrahydro-2H-pyran-2-one (Atorvastatin Lactone)
REF: 86-MM0400.01
CAS: 125995-03-1
- - -To inquireMon 10 Mar 25
TRC logo
Atorvastatin Lactone
REF: TR-A791780
CAS: 125995-03-1
- - -218.00 €~514.00 €Mon 17 Mar 25
Fluorochem logo
Atorvastatin lactone
REF: 10-F601118
CAS: 125995-03-1
98%To inquireMon 17 Mar 25
Biosynth logo
Atorvastatin lactone
REF: 3D-IA18019
CAS: 125995-03-1
Min. 98 Area-%100.00 €~1,503.00 €Tue 18 Mar 25
discount label

Ref: 47-1268

25mg211.00 €
Estimated delivery in United States, on Wednesday 5 Mar 2025
discount label

Atorvastatin Related Compound H (Lactone Impurity, 5-(4-Fluorophenyl)-1-{2-[(2R, 4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide)

CAS:125995-03-1

Ref: 45-1044582

20mg1,371.00 €
Estimated delivery in United States, on Thursday 6 Mar 2025
discount label

Atorvastatin lactone

CAS:125995-03-1

Ref: TM-T14342

2mg38.00 €
5mg51.00 €
10mg92.00 €
25mg136.00 €
50mg188.00 €
100mg283.00 €
1mL*10mM (DMSO)62.00 €
Estimated delivery in United States, on Friday 7 Mar 2025
discount label

Ref: IN-DA000QNL

1g619.00 €
25mg104.00 €
100mg155.00 €
250mg221.00 €
Estimated delivery in United States, on Friday 7 Mar 2025
discount label

Ref: 4Z-A-127

5mg309.00 €
10mg496.00 €
20mg670.00 €
25mg709.00 €
30mg819.00 €
50mg881.00 €
100mg1,288.00 €
Estimated delivery in United States, on Monday 10 Mar 2025
discount label

Ref: 4Z-A-1214

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Monday 10 Mar 2025
discount label

Atorvastatin Lactone

CAS:125995-03-1

Ref: 3B-A3114

25mg105.00 €
100mg306.00 €
Estimated delivery in United States, on Monday 10 Mar 2025
discount label

Ref: 86-MM0400.01

25mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Monday 10 Mar 2025
discount label

Atorvastatin Lactone

Controlled Product
CAS:125995-03-1

Ref: TR-A791780

10mg218.00 €
25mg267.00 €
50mg514.00 €
Estimated delivery in United States, on Monday 17 Mar 2025
discount label

Ref: 10-F601118

1gTo inquire
5mg131.00 €
10mg196.00 €
25mg99.00 €
100mgTo inquire
250mgTo inquire
Estimated delivery in United States, on Monday 17 Mar 2025
discount label

Atorvastatin lactone

CAS:125995-03-1

Ref: 3D-IA18019

1g1,050.00 €
2g1,503.00 €
100mg281.00 €
250mg488.00 €
500mg744.00 €
Estimated delivery in United States, on Tuesday 18 Mar 2025
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