CAS 125995-03-1: Atorvastatin lactone

Description: Atorvastatin lactone, with the CAS number 125995-03-1, is a chemical compound that serves as a precursor to atorvastatin, a widely used statin medication for lowering cholesterol levels. This lactone form is characterized by its cyclic ester structure, which is formed from the reaction of a carboxylic acid and an alcohol. Atorvastatin lactone exhibits lipophilic properties, allowing it to penetrate cell membranes effectively. It is typically a white to off-white solid and is soluble in organic solvents, but has limited solubility in water. The compound is known for its pharmacological activity, as it can inhibit HMG-CoA reductase, an enzyme crucial in the cholesterol biosynthesis pathway. This inhibition leads to a decrease in cholesterol production in the liver, ultimately lowering serum cholesterol levels. Additionally, atorvastatin lactone may undergo hydrolysis in biological systems to yield atorvastatin, which is the active form responsible for its therapeutic effects. As with many pharmaceuticals, the stability and reactivity of atorvastatin lactone are influenced by environmental factors such as pH and temperature.

Formula: C₃₃H₃₃FN₂O₄

InChI: InChI=1S/C33H33FN2O4/c1-21(2)31-30(33(39)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-27-19-26(37)20-28(38)40-27/h3-16,21,26-27,37H,17-20H2,1-2H3,(H,35,39)/t26-,27-/m1/s1

InChI key: InChIKey=OUCSEDFVYPBLLF-KAYWLYCHSA-N

SMILES: O=C1OC(CCN2C(C=3C=CC(F)=CC3)=C(C=4C=CC=CC4)C(C(=O)NC=5C=CC=CC5)=C2C(C)C)CC(O)C1

Synonyms:

• (4R,6R)-6-{2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-4-hydroxytetrahydro-2H-pyran-2-one
• 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-, (2R-trans)-
• 1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-
• 5-(4-Fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydropyran-2-yl]ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
• 5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
• 5-(4-fluorophenyl)-1-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-(1-methylethyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide
• 5-(4-fluorophenyl)-2-(1-methyl-ethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
• Atorvastatin d-Lactone
• Atorvastatin lactone

Atorvastatin impurity

CAS: 125995-03-1148217-40-7 344423-98-9

• Color and Shape: White

Atorvastatin impurity mixture CRS

CAS: 125995-03-1501121-34-2

Atorvastatin Related Compound H (Lactone Impurity, 5-(4-Fluorophenyl)-1-{2-[(2R, 4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide)

CAS: 125995-03-1

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

• Formula: C₃₃H₃₃FN₂O₄
• Color and Shape: White Powder
• Molecular weight: 540.24244

Atorvastatin lactone

CAS: 125995-03-1

Atorvastatin lactone is a prodrug form of atorvastatin. Which is an orally active 3-hydroxy-3-methylglutaryl coenzyme …

• Formula: C₃₃H₃₃FN₂O₄
• Purity: 98.16%
• Color and Shape: Solid
• Molecular weight: 540.62

1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-

CAS: 125995-03-1

• Formula: C₃₃H₃₃FN₂O₄
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 540.6245

Atorvastatin EP Impurity H (Atorvastatin USP Related Compound H, Atorvastatin Lactone)

CAS: 125995-03-1

• Formula: C₃₃H₃₃FN₂O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 540.64

Atorvastatin EP Impurity H-d5 (Atorvastatin USP Related Compound H-d5, Atorvastatin Lactone-d5)

CAS: 125995-03-1

• Formula: C₃₃H₂₈D₅FN₂O₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 545.67

Atorvastatin Lactone

CAS: 125995-03-1

• Formula: C₃₃H₃₃FN₂O₄
• Purity: >95.0%(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 540.64

(4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl]-4-hydroxytetrahydro-2H-pyran-2-one (Atorvastatin Lactone)

CAS: 125995-03-1

• Formula: C₃₃H₃₃FN₂O₄
• Color and Shape: Neat
• Molecular weight: 540.62

Atorvastatin Lactone

CAS: 125995-03-1

Impurity Atorvastatin EP Impurity H/ Atorvastatin Related Compound H Applications Atorvastatin Lactone (Atorvastatin EP Impurity …

• Formula: C₃₃H₃₃FN₂O₄
• Color and Shape: Off-White To Light Yellow
• Molecular weight: 540.62

Atorvastatin lactone

CAS: 125995-03-1

• Purity: 98%
• Molecular weight: 540.635009765625

Atorvastatin lactone

CAS: 125995-03-1

Please enquire for more information about Atorvastatin lactone including the price, delivery time and more …

• Formula: C₃₃H₃₃FN₂O₄
• Purity: Min. 98 Area-%
• Color and Shape: Powder
• Molecular weight: 540.62 g/mol