CAS 126-07-8

Griseofulvin

Description:

Griseofulvin is an antifungal medication primarily used to treat dermatophyte infections, particularly those affecting the skin, hair, and nails. It is derived from the mold Penicillium griseofulvum and functions by inhibiting fungal cell mitosis, thereby preventing the growth and reproduction of fungi. Griseofulvin is characterized by its crystalline structure and is typically administered orally. It is poorly soluble in water but more soluble in organic solvents, which influences its absorption and bioavailability. The substance is known for its relatively long half-life, allowing for once-daily dosing in many cases. Common side effects may include gastrointestinal disturbances, headache, and potential allergic reactions. Griseofulvin is contraindicated in certain populations, such as pregnant individuals, due to potential teratogenic effects. Its effectiveness is often assessed through clinical evaluation and laboratory tests to confirm the presence of susceptible fungal species. Overall, Griseofulvin remains a significant therapeutic option in the management of specific fungal infections.

Formula: C₁₇H₁₇ClO₆

InChI: InChI=1/C17H19ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h7-8,12H,5-6H2,1-4H3/t8-,12?,17+/m1/s1

InChI key: InChIKey=DDUHZTYCFQRHIY-RBHXEPJQSA-N

SMILES: O=C1[C@@]2(OC=3C1=C(OC)C=C(OC)C3Cl)C(OC)=CC(=O)C[C@H]2C

Synonyms:

• (1′S,6′R)-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione
• (2R,6'S)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
• (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
• (2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohexane]-3,4'-dione
• (2S,6'S)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
• 7-Chloro-2',4,6-trimethoxy-6'-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
• 7-Chloro-2',4,6-trimethoxy-6'β-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
• 7-Chloro-2′,4,6-trimethoxy-6′β-methylspiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione
• 7-chloro-2',4,6-trimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
• Amudane
• Curling factor
• Fulcin
• Fulvicin
• Fulvicin Bolus
• Fulvicin P/G
• Fulvicin U/F
• Fulvidex
• Fulvina
• Fulvinil
• Fulvistatin
• Gricin
• Grifulin
• Grifulvin
• Grifulvin V
• Gris-PEG
• Grisactin
• Grisefulin
• Griseofulvin Powder
• Griseofulvina
• Griseofulvine
• Griseovin
• Grisofulvin
• Grisovin
• Grisovin FP
• Grysio
• Idifulvin
• Lamoryl
• Likuden
• Neo-Fulcin
• Polygris
• Poncyl
• Poncyl FP
• Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S,6'R)-
• Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'S-trans)-
• Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione, 7-chloro-2',4,6-trimethoxy-6'β-methyl-
• Spiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione,7-chloro-2',4,6-trimethoxy-6'-methyl-, (1'R-trans)-
• Spiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione, 7-chloro-2′,4,6-trimethoxy-6′-methyl-, (1′S,6′R)-
• Spiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione, 7-chloro-2′,4,6-trimethoxy-6′-methyl-, (1′S-trans)-
• Spiro[benzofuran-2(3H),1′-[2]cyclohexene]-3,4′-dione, 7-chloro-2′,4,6-trimethoxy-6′β-methyl-
• Spirofulvin
• Sporostatin
• Xuanjing
• (+)-Griseofulvin
• 7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYL-, (1'S-TRANS)-SPIRO(BENZOFURAN-2(3H),1'-(2)CYCLOHEXENE)-3,4'-DIONE
• (2s-trans)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3h),1’-[2]cy
• (2S)-TRANS-7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYLSPIRO(BENZOFURAN-2[3H],1'-[2]CYCLOHEXENE)-3,4'-DIONE
• Delmofulvina
• (2s-trans)-xy-6’-methyl
• 7-chloro-4,6,2’-trimethoxy-6’-methylgris-2’-en-3,4’-dione
• curlingfactor
• 7-Chloro-2',4,6-trimethoxy-6'beta-methylspiro[benzofuran-2(3H),1'-[2]cyclohexene]-3,4'-dione
• [2S-TRANS]-7-CHLORO-2,4,6-TRIMETHOXY-6'-METHYLSPIRO[BENZOFURAN-2(3H), 1'(2)-CYCLOHEXANE]-3,4'-DIONE
• (+)-griseofulvi
• -6’-beta-methyl-
• 7-Chloro-4,6,2'-trimethoxy-6'-methylgris-2'-en-3,4'-dione
• 2’-en-4’-one)
• clohexene]-3,4’-dione
• 6-dimethoxycoumaran-3-one-2-spiro-1’-(2’-methoxy-6’-methylcyclohex-7-chloro-

(+)-Griseofulvin

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 352.77

Ref: 3B-G0384

(+)-Griseofulvin, 97%

CAS: 126-07-8

Griseofulvin is an antifungal drug. It is used both in animal and in humans, to treat ringworm infections of the skin and nails. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy br

Formula: C₁₇H₁₉ClO₆

Purity: 97%

Color and Shape: White, Powder

Molecular weight: 354.78

Ref: 02-B23521

Griseofulvin

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Purity: 99.11%

Color and Shape: Brownish. Powder

Molecular weight: 353.0

Ref: 8R-CL0363

Griseofulvin

CAS: 126-07-8

Color and Shape: Neat

Ref: 61-FOR0582.00

GRISEOFULVIN RS

CAS: 126-07-8

GRISEOFULVIN RS

Formula: C₁₇H₁₇ClO₆

Molecular weight: 352.7663

Ref: 41-ICRS0322

Griseofulvin

CAS: 126-07-8

Antibiotics nesoi

Formula: C₁₇H₁₇ClO₆

Color and Shape: White Cream Powder

Molecular weight: 352.07137

Ref: 45-1299007

Griseofulvin Permeability Diameter

CAS: 126-07-8

Antibiotics nesoi

Formula: C₁₇H₁₇ClO₆

Color and Shape: White Off-White Powder

Molecular weight: 352.77

Ref: 45-1299200

(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H-spiro[1-benzofuran-2,1'-cyclohexan]-2'-ene-3,4'-dione

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 352.7663

Ref: IN-DA0032AV

Griseofulvin

CAS: 126-07-8

Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections.

Formula: C₁₇H₁₇ClO₆

Purity: 97.06% - 98.12%

Color and Shape: Stout Octahedra Or Rhombs From Benzene

Molecular weight: 352.77

Ref: TM-T1382

Griseofulvin

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Color and Shape: White To Off-White Solid

Molecular weight: 352.77

Ref: 4Z-G-082

Griseofulvin-13C-d3

CAS: 126-07-8

Formula: C₁₆₁₃CH₁₄D₃ClO₆

Color and Shape: White To Off-White Solid

Molecular weight: 356.78

Ref: 4Z-G-088

Griseofulvin, EP grade

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Purity: ≤ 0.75%

Color and Shape: White or pale yellow powder

Molecular weight: 352.77

Ref: 7W-GA3498

(+)-Griseofulvin

CAS: 126-07-8

(+)-Griseofulvin

Purity: 98%

Molecular weight: 352.77g/mol

Ref: 54-OR1029322

Griseofulvin

CAS: 126-07-8

Griseofulvin

Purity: ≥95%

Molecular weight: 352.77g/mol

Ref: 54-BUP18502

Griseofulvin

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Purity: 97.0 - 102.0 % (dried basis)

Color and Shape: White or off-white powder

Molecular weight: 352.77

Ref: 7W-GA6599

Griseofulvin

Controlled Product

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Color and Shape: Neat

Molecular weight: 352.77

Ref: 86-MM0582.00

Griseofulvin 100 µg/mL in Acetonitrile

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Color and Shape: Single Solution

Molecular weight: 352.77

Ref: 04-V14056500AL-100

Griseofulvin

Controlled Product

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Color and Shape: Neat

Molecular weight: 352.77

Ref: 04-C14056500

Griseofulvin

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Ref: TR-TRC-G787500

Griseofulvin

Controlled Product

CAS: 126-07-8

Applications It is an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.Environmental contaminants; Food contaminants
References Oxford, et al.: Biochem. J., 33, 240 (1939), Townley, E.R., et al.: Anal. Profiles Drug Subs., 8, 219 (1979),

Formula: C₁₇H₁₇ClO₆

Color and Shape: Off-White

Molecular weight: 352.77

Ref: TR-G787500

Griseofulvin

CAS: 126-07-8

Anti-fungal; microtubule polymerization inhibitor

Formula: C₁₇H₁₇ClO₆

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 352.77 g/mol

Ref: 3D-FG23704

Griseofulvin - Bio-X ™

CAS: 126-07-8

Griseofulvin is an antifungal drug used to treat several types of dermatophytosis (ringworm). This includes fungal infections of the nails, scalp and the skin when antifungal creams have not worked. It is suggested that it prevents nuclear acid production and fungal cell mitosis. Additionally, through binding to alpha and beta tubulin, it interferes with the function of the spindle and cytoplasmic microtubules.

Formula: C₁₇H₁₇ClO₆

Purity: Min. 97 Area-%

Color and Shape: Powder

Molecular weight: 352.77 g/mol

Ref: 3D-BT164513

(2S,6’R)-7-chloro-2′,4,6-trimethoxy-6′-methyl-3H-spiro[1-benzofuran-2,1′-cyclohexan]-2′-ene-3,4′-dione

CAS: 126-07-8

Formula: C₁₇H₁₇ClO₆

Purity: 95%

Color and Shape: Solid

Molecular weight: 352.77

Ref: 10-F354301

Griseofulvin

CAS: 126-07-8

Griseofulvin

Formula: C₁₇H₁₇ClO₆

Purity: 99.8% / 98.3%

Color and Shape: White

Molecular weight: 352.07137

Ref: 47-180