CAS 1260251-31-7

Birinapant

Description:

Birinapant is a small-molecule compound classified as a dual inhibitor of the cellular inhibitors of apoptosis proteins (IAPs), specifically targeting IAP1 and IAP2. It is primarily investigated for its potential in cancer therapy, particularly in enhancing the efficacy of other anticancer agents by promoting apoptosis in tumor cells. Birinapant functions by disrupting the IAPs' ability to inhibit caspases, which are crucial enzymes in the apoptotic pathway. This mechanism of action makes it a candidate for combination therapies, especially in malignancies resistant to conventional treatments. The compound is typically administered via intravenous injection and has been evaluated in various clinical trials for its safety and effectiveness in treating different types of cancer. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are essential for understanding its therapeutic potential and optimizing dosing regimens. Overall, Birinapant represents a promising approach in the field of targeted cancer therapies, aiming to overcome resistance mechanisms in tumor cells.

Propanamide, N,N'-[(6,6'-difluoro[2,2'-bi-1H-indole]-3,3'-diyl)bis[methylene[(2R,4S)-4-hydroxy-2,1-pyrrolidinediyl][(1S)-1-ethyl-2-oxo-2,1-ethanediyl]]]bis[2-(methylamino)-, (2S,2'S)-

CAS: 1260251-31-7

Formula: C₄₂H₅₆F₂N₈O₆

Purity: %

Color and Shape: Solid

Molecular weight: 806.9408

Ref: IN-DA000QRV

Birinapant

CAS: 1260251-31-7

Birinapant

Purity: ≥95%

Molecular weight: 806.94g/mol

Ref: 54-BUP10037

Birinapant

CAS: 1260251-31-7

Birinapant (TL32711) is a synthetic small molecule that is both a peptidomimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of

Formula: C₄₂H₅₆F₂N₈O₆

Purity: 97.08% - ≥95%

Color and Shape: Solid

Molecular weight: 806.94

Ref: TM-T6007

Birinapant

Controlled Product

CAS: 1260251-31-7

Applications Birinapant is a bivalent SMAC mimetic compound antagonist of TRAF2 associated cIAP1 and cIAP2.
References Benetatos, C.A., et. al.: Mol. Cancer Ther., 13, 867 (2014)

Formula: C₄₂H₅₆F₂N₈O₆

Color and Shape: Neat

Molecular weight: 806.94

Ref: TR-B399730