CAS 1260588-15-5

Paricalcitol 25-b-D-glucuronide

CAS: 1260588-15-5

Ref: 7W-GC8641

Paricalcitol 25-β-D-Glucuronide

Controlled Product

CAS: 1260588-15-5

Applications The glucuonide metabolite of Paricalcitol (P195300) in mammalian bile.
References LeVan L.W., et al.: Biochemistry, 20, 222 (1981), Litwiller, R.D., J. Biol. Chem., 257, 7491 (1982),

Formula: C₃₃H₅₂O₉

Color and Shape: Neat

Molecular weight: 592.761

Ref: TR-P195310

Paricalcitol 25-b-D-glucuronide

CAS: 1260588-15-5

Paricalcitol 25-b-D-glucuronide is a synthetic analogue of calcitriol, which is the active form of vitamin D. It is a high-purity glycosylate with an average molecular weight of 522.5 Da and a purity of >98%. Paricalcitol 25-b-D-glucuronide has been shown to be effective in prevention or treatment of secondary hyperparathyroidism in patients with chronic kidney disease (CKD). This compound has shown to inhibit calcium absorption in the gut and increase urinary excretion of calcium. It also increases serum phosphate levels, which may lead to increased calcium phosphate deposition in bone. Paricalcitol 25-b-D-glucuronide is methylated at the 25 position, which prevents it from being metabolized by the liver. This modification allows for higher concentrations to be administered without causing toxicity.

Formula: C₃₃H₅₂O₉

Purity: Min. 95%

Molecular weight: 592.76 g/mol

Ref: 3D-MP16829