CAS 1260601-13-5

Fmoc-2,4-difluoro-D-homophenylalanine

Description:

Fmoc-2,4-difluoro-D-homophenylalanine is a synthetic amino acid derivative commonly used in peptide synthesis and drug development. It features a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group, which is widely utilized in solid-phase peptide synthesis due to its stability under basic conditions and ease of removal under acidic conditions. The presence of two fluorine atoms at the 2 and 4 positions of the aromatic ring enhances the compound's lipophilicity and can influence its biological activity, making it of interest in medicinal chemistry. The D-homophenylalanine structure contributes to its unique stereochemistry, which can affect peptide conformation and interactions with biological targets. This compound is typically characterized by its solid-state properties, including melting point and solubility in organic solvents, and can be analyzed using techniques such as NMR spectroscopy and mass spectrometry. Overall, Fmoc-2,4-difluoro-D-homophenylalanine serves as a valuable building block in the synthesis of peptides with potential therapeutic applications.

Formula: C₂₅H₂₁F₂NO₄

Synonyms:

• Fmoc-2,4-difluoro-D-homophenylalanine
• (2R)-4-(2,4-difluorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)butanoic acid
• Benzenebutanoic acid, α-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2,4-difluoro-, (αR)-
• (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2,4-difluorophenyl)butanoic acid