CAS 1260618-19-6

Boc-2,4-difluoro-D-homophenylalanine

Description:

Boc-2,4-difluoro-D-homophenylalanine is a synthetic amino acid derivative characterized by the presence of a tert-butyloxycarbonyl (Boc) protecting group, which is commonly used in peptide synthesis to protect the amino group. The compound features a difluorinated phenylalanine structure, where two fluorine atoms are substituted at the 2 and 4 positions of the aromatic ring, enhancing its lipophilicity and potentially influencing its biological activity. The "D" designation indicates that this is the D-enantiomer of homophenylalanine, which is a non-proteinogenic amino acid. This compound is often utilized in the development of peptides and proteins with specific properties, particularly in medicinal chemistry and drug design, due to its unique electronic and steric characteristics. Its fluorinated nature can also improve metabolic stability and alter the pharmacokinetics of peptides. As with many fluorinated compounds, it may exhibit distinct interactions with biological targets, making it a valuable tool in research and therapeutic applications.

Formula: C₁₅H₁₉F₂NO₄

Synonyms:

• (R)-2-((tert-butoxycarbonyl)amino)-4-(2,4-difluorophenyl)butanoic acid
• Benzenebutanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-2,4-difluoro-, (αR)-
• Boc-2,4-difluoro-D-homophenylalanine
• (2R)-2-{[(tert-butoxy)carbonyl]amino}-4-(2,4-difluorophenyl)butanoic acid