CAS 126088-82-2

N(alpha)-(N(alpha)-(N(alpha)-(tert-butyloxycarbonyl)glutaminyl)-N(1)-formyl-tryptophyl)phenylalanine benzyl ester

Description:

The chemical substance known as N(alpha)-(N(alpha)-(N(alpha)-(tert-butyloxycarbonyl)glutaminyl)-N(1)-formyl-tryptophyl)phenylalanine benzyl ester, with CAS number 126088-82-2, is a complex peptide derivative. It features a tert-butyloxycarbonyl (Boc) protecting group, which is commonly used in peptide synthesis to protect the amino group of glutamine, enhancing stability during reactions. The structure includes a formyl group attached to tryptophan, indicating a modification that can influence the peptide's reactivity and biological activity. The presence of a phenylalanine benzyl ester moiety suggests potential lipophilicity, which may affect the compound's solubility and permeability. This compound is likely to be of interest in biochemical research, particularly in studies related to peptide synthesis, drug design, or as a potential therapeutic agent. Its intricate structure may also imply specific interactions with biological targets, making it a candidate for further investigation in pharmacological applications. Overall, this substance exemplifies the complexity and versatility of peptide chemistry in medicinal chemistry and biochemistry.

Formula: C₃₈H₄₃N₅O₈

InChI: InChI=1/C38H43N5O8/c1-38(2,3)51-37(49)42-29(18-19-33(39)45)34(46)40-30(21-27-22-43(24-44)32-17-11-10-16-28(27)32)35(47)41-31(20-25-12-6-4-7-13-25)36(48)50-23-26-14-8-5-9-15-26/h4-17,22,24,29-31H,18-21,23H2,1-3H3,(H2,39,45)(H,40,46)(H,41,47)(H,42,49)/t29-,30+,31-/m0/s1

Synonyms:

• Bgtcpo
• Boc-gln-trp(cho)-phe-obzl
• N-(N-(N2-((1,1-Dimethylethoxy)carbonyl)-L-glutaminyl)-1-formyl-D-tryptophyl)-L-phenylalanine phenylmethyl ester
• L-Phenylalanine, N-(N-(N2-((1,1-dimethylethoxy)carbonyl)-L-glutaminyl)-1-formyl-D-tryptophyl)-, phenylmethyl ester
• benzyl N~2~-(tert-butoxycarbonyl)-L-glutaminyl-1-formyl-D-tryptophyl-L-phenylalaninate
• N(alpha)-(N(alpha)-(N(alpha)-(tert-Butyloxycarbonyl)glutaminyl)-N(1)-formyl-tryptophyl)phenylalanine benzyl ester
• QWF
• L-Phenylalanine, N2-[(1,1-dimethylethoxy)carbonyl]-L-glutaminyl-1-formyl-D-tryptophyl-, phenylmethyl ester

QWF

CAS: 126088-82-2

Tripeptide SP antagonist (IC50: 90 μM); blocks SP-MRGPR X2 binding and mast cell degranulation; reduces 48/80-induced scratching in mice.

Formula: C₃₈H₄₃N₅O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 697.78

Ref: TM-TP1946

QWF

CAS: 126088-82-2

QWF is a chiral compound that has been shown to have potent inhibitory activity against neurokinin-1 receptor (NK-1R). QWF has been shown to stimulate degranulation of cells and to act as a polymerization initiator. It also has optical properties that are sensitive to the wavelength of light, which can be used in an optical system with a polarizer. QWF can be used as a carbon source for growth and is reactive, making it difficult to store.

Formula: C₃₈H₄₃N₅O₈

Purity: Min. 95%

Molecular weight: 697.8 g/mol

Ref: 3D-BFA08882