CAS 1260907-17-2

(4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide

Description:

The chemical substance known as (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide, with the CAS number 1260907-17-2, is a member of the benzodiazepine family, characterized by its complex triazole and benzodiazepine structure. This compound typically exhibits properties such as high lipophilicity, which may influence its bioavailability and pharmacokinetics. The presence of the 4-chlorophenyl group suggests potential interactions with biological targets, possibly enhancing its pharmacological activity. The methoxy and ethyl substituents contribute to its overall molecular stability and may affect its binding affinity to receptors. As a benzodiazepine derivative, it may possess anxiolytic, sedative, or anticonvulsant properties, although specific biological activities would depend on further empirical studies. The stereochemistry indicated by the (4S) configuration suggests that the compound may exhibit chirality, which can significantly influence its pharmacodynamics and therapeutic effects. Overall, this compound represents a unique structure with potential applications in medicinal chemistry and pharmacology.

Formula: C₂₂H₂₂ClN₅O₂

InChI: InChI=1S/C22H22ClN5O2/c1-4-24-20(29)12-18-22-27-26-13(2)28(22)19-10-9-16(30-3)11-17(19)21(25-18)14-5-7-15(23)8-6-14/h5-11,18H,4,12H2,1-3H3,(H,24,29)/t18-/m0/s1

InChI key: InChIKey=AAAQFGUYHFJNHI-SFHVURJKSA-N

SMILES: O(C)C=1C=C2C(N3C([C@H](CC(NCC)=O)N=C2C4=CC=C(Cl)C=C4)=NN=C3C)=CC1

Synonyms:

• (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
• 4H-[1,2,4]Triazolo[4,3-a][1,4]benzodiazepine-4-acetamide, 6-(4-chlorophenyl)-N-ethyl-8-methoxy-1-methyl-, (4S)-
• I-BET 762
• GSK 525762A
• iBET

Molibresib

CAS: 1260907-17-2

Formula: C₂₂H₂₂ClN₅O₂

Purity: %

Color and Shape: Solid

Molecular weight: 423.8954

Ref: IN-DA000RLX

Molibresib

CAS: 1260907-17-2

Molibresib

Purity: ≥95%

Molecular weight: 423.9g/mol

Ref: 54-BUP12090

I-BET762

CAS: 1260907-17-2

Ref: 7W-GW4589

Molibresib

CAS: 1260907-17-2

Molibresib (GSK525762) is an inhibitor of BET proteins (IC50: about 35 nM).

Formula: C₂₂H₂₂ClN₅O₂

Purity: 97.70% - 99.08%

Color and Shape: Solid

Molecular weight: 423.9

Ref: TM-T1906

Molibresib

CAS: 1260907-17-2

Molecular weight: 423.899993896484

Ref: 10-F865570

GSK 525762A-d5

Controlled Product

CAS: 1260907-17-2

Formula: C₂₂D₅H₁₇ClN₅O₂

Color and Shape: Neat

Molecular weight: 428.926

Ref: TR-G797507

GSK 525762A

Controlled Product

CAS: 1260907-17-2

Applications GSK 525762A, is a BET Bromodomain Inhibitor, which is now in clinical development. BET bromodomains have emerged as promising drug targets for treatment of cancers, inflammatory diseases, and other medical conditions.
References Zhao, Y., et al.: J. Med. Chem., 56, 7498 (2013); Mirguet, O., et al.: J. Med. Chem., 56, 7501 (2013);

Formula: C₂₂H₂₂ClN₅O₂

Color and Shape: Neat

Molecular weight: 423.9

Ref: TR-G797505

I-BET 762

Controlled Product

CAS: 1260907-17-2

Inhibitor of BET bromodomain

Formula: C₂₂H₂₂ClN₅O₂

Purity: Min. 95%

Molecular weight: 423.9 g/mol

Ref: 3D-FG137683